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Evaluating coverage bias in next-generation sequencing of Escherichia coli

Whole-genome sequencing is essential to many facets of infectious disease research. However, technical limitations such as bias in coverage and tagmentation, and difficulties characterising genomic regions with extreme GC content have created significant obstacles in its use. Illumina has claimed th...

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Detalles Bibliográficos
Autores principales:	Gunasekera, Samantha, Abraham, Sam, Stegger, Marc, Pang, Stanley, Wang, Penghao, Sahibzada, Shafi, O’Dea, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224930/ https://www.ncbi.nlm.nih.gov/pubmed/34166413 http://dx.doi.org/10.1371/journal.pone.0253440

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