Cargando…
The Roles of Various Prostaglandins in Fibrosis: A Review
Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by a...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225152/ https://www.ncbi.nlm.nih.gov/pubmed/34073892 http://dx.doi.org/10.3390/biom11060789 |
_version_ | 1783712035713843200 |
---|---|
author | Li, Ke Zhao, Jing Wang, Mingxuan Niu, Lingzhi Wang, Yuanping Li, Yanxia Zheng, Yajuan |
author_facet | Li, Ke Zhao, Jing Wang, Mingxuan Niu, Lingzhi Wang, Yuanping Li, Yanxia Zheng, Yajuan |
author_sort | Li, Ke |
collection | PubMed |
description | Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis. |
format | Online Article Text |
id | pubmed-8225152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82251522021-06-25 The Roles of Various Prostaglandins in Fibrosis: A Review Li, Ke Zhao, Jing Wang, Mingxuan Niu, Lingzhi Wang, Yuanping Li, Yanxia Zheng, Yajuan Biomolecules Review Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis. MDPI 2021-05-24 /pmc/articles/PMC8225152/ /pubmed/34073892 http://dx.doi.org/10.3390/biom11060789 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Ke Zhao, Jing Wang, Mingxuan Niu, Lingzhi Wang, Yuanping Li, Yanxia Zheng, Yajuan The Roles of Various Prostaglandins in Fibrosis: A Review |
title | The Roles of Various Prostaglandins in Fibrosis: A Review |
title_full | The Roles of Various Prostaglandins in Fibrosis: A Review |
title_fullStr | The Roles of Various Prostaglandins in Fibrosis: A Review |
title_full_unstemmed | The Roles of Various Prostaglandins in Fibrosis: A Review |
title_short | The Roles of Various Prostaglandins in Fibrosis: A Review |
title_sort | roles of various prostaglandins in fibrosis: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225152/ https://www.ncbi.nlm.nih.gov/pubmed/34073892 http://dx.doi.org/10.3390/biom11060789 |
work_keys_str_mv | AT like therolesofvariousprostaglandinsinfibrosisareview AT zhaojing therolesofvariousprostaglandinsinfibrosisareview AT wangmingxuan therolesofvariousprostaglandinsinfibrosisareview AT niulingzhi therolesofvariousprostaglandinsinfibrosisareview AT wangyuanping therolesofvariousprostaglandinsinfibrosisareview AT liyanxia therolesofvariousprostaglandinsinfibrosisareview AT zhengyajuan therolesofvariousprostaglandinsinfibrosisareview AT like rolesofvariousprostaglandinsinfibrosisareview AT zhaojing rolesofvariousprostaglandinsinfibrosisareview AT wangmingxuan rolesofvariousprostaglandinsinfibrosisareview AT niulingzhi rolesofvariousprostaglandinsinfibrosisareview AT wangyuanping rolesofvariousprostaglandinsinfibrosisareview AT liyanxia rolesofvariousprostaglandinsinfibrosisareview AT zhengyajuan rolesofvariousprostaglandinsinfibrosisareview |