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Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost
In this study, we investigated the effect of preservative-free (PF) 0.0015% tafluprost (TA), to the preservative containing (PC) and the PF 0.005% latanoprost (LA) in Korean subjects. This study was conducted as a multi-center, randomized, investigator-blind, active controlled, parallel-group, clini...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225154/ https://www.ncbi.nlm.nih.gov/pubmed/34073977 http://dx.doi.org/10.3390/ph14060501 |
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author | Kim, Joon Mo Park, Sang Woo Seong, Mincheol Ha, Seung Joo Lee, Ji Woong Rho, Seungsoo Lee, Chong Eun Kim, Kyoung Nam Kim, Tae-Woo Sung, Kyung Rim Kim, Chan Yun |
author_facet | Kim, Joon Mo Park, Sang Woo Seong, Mincheol Ha, Seung Joo Lee, Ji Woong Rho, Seungsoo Lee, Chong Eun Kim, Kyoung Nam Kim, Tae-Woo Sung, Kyung Rim Kim, Chan Yun |
author_sort | Kim, Joon Mo |
collection | PubMed |
description | In this study, we investigated the effect of preservative-free (PF) 0.0015% tafluprost (TA), to the preservative containing (PC) and the PF 0.005% latanoprost (LA) in Korean subjects. This study was conducted as a multi-center, randomized, investigator-blind, active controlled, parallel-group, clinical trial in adult patients (≥19 years) with open-angle glaucoma (OAG) and ocular hypertension (OHT). After a washout period, patients with an IOP between 15 and 35 mmHg were enrolled and evaluated the efficacy, safety, and compliance at 4, 8 and 12 weeks after the first administration. A total of 137 OAG and OHT patients were randomized. Statistically significant reductions in IOP were observed in all groups. Twelve weeks after each eye drop instillation, the mean IOP reduction was −4.59 ± 2.70 mmHg (−24.57 ± 13.49%) in the PC-LA group, −4.52 ± 2.17 mmHg (−24.41 ± 11.38%) in the PF-LA, and −3.14 ± 2.83 mmHg (−17.22 ± 14.57%) in the PF-TA group. The PF-LA showed significantly better responsiveness than did PF-TA. PF-LA was better tolerated than was PC-LA. There were no adverse events that led to cessation of eye drop use in any of the groups. In conclusion, IOP decreased similarly across the groups. PF-LA may provide a good choice for OAG patients with ocular surface diseases. |
format | Online Article Text |
id | pubmed-8225154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82251542021-06-25 Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost Kim, Joon Mo Park, Sang Woo Seong, Mincheol Ha, Seung Joo Lee, Ji Woong Rho, Seungsoo Lee, Chong Eun Kim, Kyoung Nam Kim, Tae-Woo Sung, Kyung Rim Kim, Chan Yun Pharmaceuticals (Basel) Article In this study, we investigated the effect of preservative-free (PF) 0.0015% tafluprost (TA), to the preservative containing (PC) and the PF 0.005% latanoprost (LA) in Korean subjects. This study was conducted as a multi-center, randomized, investigator-blind, active controlled, parallel-group, clinical trial in adult patients (≥19 years) with open-angle glaucoma (OAG) and ocular hypertension (OHT). After a washout period, patients with an IOP between 15 and 35 mmHg were enrolled and evaluated the efficacy, safety, and compliance at 4, 8 and 12 weeks after the first administration. A total of 137 OAG and OHT patients were randomized. Statistically significant reductions in IOP were observed in all groups. Twelve weeks after each eye drop instillation, the mean IOP reduction was −4.59 ± 2.70 mmHg (−24.57 ± 13.49%) in the PC-LA group, −4.52 ± 2.17 mmHg (−24.41 ± 11.38%) in the PF-LA, and −3.14 ± 2.83 mmHg (−17.22 ± 14.57%) in the PF-TA group. The PF-LA showed significantly better responsiveness than did PF-TA. PF-LA was better tolerated than was PC-LA. There were no adverse events that led to cessation of eye drop use in any of the groups. In conclusion, IOP decreased similarly across the groups. PF-LA may provide a good choice for OAG patients with ocular surface diseases. MDPI 2021-05-24 /pmc/articles/PMC8225154/ /pubmed/34073977 http://dx.doi.org/10.3390/ph14060501 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Joon Mo Park, Sang Woo Seong, Mincheol Ha, Seung Joo Lee, Ji Woong Rho, Seungsoo Lee, Chong Eun Kim, Kyoung Nam Kim, Tae-Woo Sung, Kyung Rim Kim, Chan Yun Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title | Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title_full | Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title_fullStr | Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title_full_unstemmed | Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title_short | Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost |
title_sort | comparison of the safety and efficacy between preserved and preservative-free latanoprost and preservative-free tafluprost |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225154/ https://www.ncbi.nlm.nih.gov/pubmed/34073977 http://dx.doi.org/10.3390/ph14060501 |
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