Enhancing Metabolic Imaging of Energy Metabolism in Traumatic Brain Injury Using Hyperpolarized [1-(13)C]Pyruvate and Dichloroacetate

Hyperpolarized magnetic resonance spectroscopic imaging (MRSI) of [1-(13)C]pyruvate metabolism has previously been used to assess the effects of traumatic brain injury (TBI) in rats. Here, we show that MRSI can be used in conjunction with dichloroacetate to measure the phosphorylation state of pyruv...

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Detalles Bibliográficos
Autores principales: DeVience, Stephen J., Lu, Xin, Proctor, Julie L., Rangghran, Parisa, Medina, Juliana A., Melhem, Elias R., Gullapalli, Rao P., Fiskum, Gary, Mayer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225170/
https://www.ncbi.nlm.nih.gov/pubmed/34073714
http://dx.doi.org/10.3390/metabo11060335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225170/
https://www.ncbi.nlm.nih.gov/pubmed/34073714
http://dx.doi.org/10.3390/metabo11060335

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