Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy receptor by binding collagen with higher affinity than LAIR-1....

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Detalles Bibliográficos
Autores principales: Ramos, M Ines Pascoal, Tian, Linjie, de Ruiter, Emma J, Song, Chang, Paucarmayta, Ana, Singh, Akashdip, Elshof, Eline, Vijver, Saskia V, Shaik, Jahangheer, Bosiacki, Jason, Cusumano, Zachary, Jensen, Christina, Willumsen, Nicholas, Karsdal, Morten A, Liu, Linda, Langermann, Sol, Willems, Stefan, Flies, Dallas, Meyaard, Linde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225389/
https://www.ncbi.nlm.nih.gov/pubmed/34121658
http://dx.doi.org/10.7554/eLife.62927

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