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Behavioral and Neural Variability of Naturalistic Arm Movements

Motor behaviors are central to many functions and dysfunctions of the brain, and understanding their neural basis has consequently been a major focus in neuroscience. However, most studies of motor behaviors have been restricted to artificial, repetitive paradigms, far removed from natural movements...

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Autores principales: Peterson, Steven M., Singh, Satpreet H., Wang, Nancy X. R., Rao, Rajesh P. N., Brunton, Bingni W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225404/
https://www.ncbi.nlm.nih.gov/pubmed/34031100
http://dx.doi.org/10.1523/ENEURO.0007-21.2021
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author Peterson, Steven M.
Singh, Satpreet H.
Wang, Nancy X. R.
Rao, Rajesh P. N.
Brunton, Bingni W.
author_facet Peterson, Steven M.
Singh, Satpreet H.
Wang, Nancy X. R.
Rao, Rajesh P. N.
Brunton, Bingni W.
author_sort Peterson, Steven M.
collection PubMed
description Motor behaviors are central to many functions and dysfunctions of the brain, and understanding their neural basis has consequently been a major focus in neuroscience. However, most studies of motor behaviors have been restricted to artificial, repetitive paradigms, far removed from natural movements performed “in the wild.” Here, we leveraged recent advances in machine learning and computer vision to analyze intracranial recordings from 12 human subjects during thousands of spontaneous, unstructured arm reach movements, observed over several days for each subject. These naturalistic movements elicited cortical spectral power patterns consistent with findings from controlled paradigms, but with considerable neural variability across subjects and events. We modeled interevent variability using 10 behavioral and environmental features; the most important features explaining this variability were reach angle and day of recording. Our work is among the first studies connecting behavioral and neural variability across cortex in humans during unstructured movements and contributes to our understanding of long-term naturalistic behavior.
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spelling pubmed-82254042021-06-25 Behavioral and Neural Variability of Naturalistic Arm Movements Peterson, Steven M. Singh, Satpreet H. Wang, Nancy X. R. Rao, Rajesh P. N. Brunton, Bingni W. eNeuro Research Article: New Research Motor behaviors are central to many functions and dysfunctions of the brain, and understanding their neural basis has consequently been a major focus in neuroscience. However, most studies of motor behaviors have been restricted to artificial, repetitive paradigms, far removed from natural movements performed “in the wild.” Here, we leveraged recent advances in machine learning and computer vision to analyze intracranial recordings from 12 human subjects during thousands of spontaneous, unstructured arm reach movements, observed over several days for each subject. These naturalistic movements elicited cortical spectral power patterns consistent with findings from controlled paradigms, but with considerable neural variability across subjects and events. We modeled interevent variability using 10 behavioral and environmental features; the most important features explaining this variability were reach angle and day of recording. Our work is among the first studies connecting behavioral and neural variability across cortex in humans during unstructured movements and contributes to our understanding of long-term naturalistic behavior. Society for Neuroscience 2021-06-19 /pmc/articles/PMC8225404/ /pubmed/34031100 http://dx.doi.org/10.1523/ENEURO.0007-21.2021 Text en Copyright © 2021 Peterson et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Peterson, Steven M.
Singh, Satpreet H.
Wang, Nancy X. R.
Rao, Rajesh P. N.
Brunton, Bingni W.
Behavioral and Neural Variability of Naturalistic Arm Movements
title Behavioral and Neural Variability of Naturalistic Arm Movements
title_full Behavioral and Neural Variability of Naturalistic Arm Movements
title_fullStr Behavioral and Neural Variability of Naturalistic Arm Movements
title_full_unstemmed Behavioral and Neural Variability of Naturalistic Arm Movements
title_short Behavioral and Neural Variability of Naturalistic Arm Movements
title_sort behavioral and neural variability of naturalistic arm movements
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225404/
https://www.ncbi.nlm.nih.gov/pubmed/34031100
http://dx.doi.org/10.1523/ENEURO.0007-21.2021
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