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EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth

Phase-amplitude coupling (PAC), the coupling of the phase of slower electrophysiological oscillations with the amplitude of faster oscillations, is thought to facilitate dynamic integration of neural activity in the brain. Although the brain undergoes dramatic change and development during the first...

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Autores principales: Mariscal, Michael G., Levin, April R., Gabard-Durnam, Laurel J., Xie, Wanze, Tager-Flusberg, Helen, Nelson, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225408/
https://www.ncbi.nlm.nih.gov/pubmed/34049989
http://dx.doi.org/10.1523/ENEURO.0264-20.2021
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author Mariscal, Michael G.
Levin, April R.
Gabard-Durnam, Laurel J.
Xie, Wanze
Tager-Flusberg, Helen
Nelson, Charles A.
author_facet Mariscal, Michael G.
Levin, April R.
Gabard-Durnam, Laurel J.
Xie, Wanze
Tager-Flusberg, Helen
Nelson, Charles A.
author_sort Mariscal, Michael G.
collection PubMed
description Phase-amplitude coupling (PAC), the coupling of the phase of slower electrophysiological oscillations with the amplitude of faster oscillations, is thought to facilitate dynamic integration of neural activity in the brain. Although the brain undergoes dramatic change and development during the first few years of life, how PAC changes through this developmental period has not been extensively studied. Here, we examined PAC through electroencephalography (EEG) data collected during an awake, eyes-open EEG collection paradigm in 98 children between the ages of three months and three years. We employed non-parametric clustering methods to identify areas of significant PAC across a range of frequency pairs and electrode locations, and examined how PAC strength and phase preference develops in these areas. We found that PAC, primarily between the α-β and γ frequencies, was positively correlated with age from early infancy to early childhood (p = 2.035 × 10(−6)). Additionally, we found γ over anterior electrodes coupled with the rising phase of the α-β waveform, while γ over posterior electrodes coupled with the falling phase of the α-β waveform; this regionalized phase preference became more prominent with age. This opposing trend may reflect each region’s specialization toward feedback or feedforward processing, respectively, suggesting opportunities for back translation in future studies.
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spelling pubmed-82254082021-06-25 EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth Mariscal, Michael G. Levin, April R. Gabard-Durnam, Laurel J. Xie, Wanze Tager-Flusberg, Helen Nelson, Charles A. eNeuro Research Article: New Research Phase-amplitude coupling (PAC), the coupling of the phase of slower electrophysiological oscillations with the amplitude of faster oscillations, is thought to facilitate dynamic integration of neural activity in the brain. Although the brain undergoes dramatic change and development during the first few years of life, how PAC changes through this developmental period has not been extensively studied. Here, we examined PAC through electroencephalography (EEG) data collected during an awake, eyes-open EEG collection paradigm in 98 children between the ages of three months and three years. We employed non-parametric clustering methods to identify areas of significant PAC across a range of frequency pairs and electrode locations, and examined how PAC strength and phase preference develops in these areas. We found that PAC, primarily between the α-β and γ frequencies, was positively correlated with age from early infancy to early childhood (p = 2.035 × 10(−6)). Additionally, we found γ over anterior electrodes coupled with the rising phase of the α-β waveform, while γ over posterior electrodes coupled with the falling phase of the α-β waveform; this regionalized phase preference became more prominent with age. This opposing trend may reflect each region’s specialization toward feedback or feedforward processing, respectively, suggesting opportunities for back translation in future studies. Society for Neuroscience 2021-06-17 /pmc/articles/PMC8225408/ /pubmed/34049989 http://dx.doi.org/10.1523/ENEURO.0264-20.2021 Text en Copyright © 2021 Mariscal et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Mariscal, Michael G.
Levin, April R.
Gabard-Durnam, Laurel J.
Xie, Wanze
Tager-Flusberg, Helen
Nelson, Charles A.
EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title_full EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title_fullStr EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title_full_unstemmed EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title_short EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth
title_sort eeg phase-amplitude coupling strength and phase preference: association with age over the first three years after birth
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225408/
https://www.ncbi.nlm.nih.gov/pubmed/34049989
http://dx.doi.org/10.1523/ENEURO.0264-20.2021
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