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Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma

We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining fo...

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Autores principales: Maeng, Young-In, Lee, Sun-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yeungnam University College of Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225494/
https://www.ncbi.nlm.nih.gov/pubmed/32911592
http://dx.doi.org/10.12701/yujm.2020.00675
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author Maeng, Young-In
Lee, Sun-Jae
author_facet Maeng, Young-In
Lee, Sun-Jae
author_sort Maeng, Young-In
collection PubMed
description We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)–encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.
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spelling pubmed-82254942021-07-06 Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma Maeng, Young-In Lee, Sun-Jae Yeungnam Univ J Med Case Report We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)–encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH. Yeungnam University College of Medicine 2020-09-11 /pmc/articles/PMC8225494/ /pubmed/32911592 http://dx.doi.org/10.12701/yujm.2020.00675 Text en Copyright © 2021 Yeungnam University College of Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maeng, Young-In
Lee, Sun-Jae
Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title_full Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title_fullStr Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title_full_unstemmed Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title_short Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
title_sort metachronous extranodal natural killer/t-cell lymphoma of nasal type and primary testicular lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225494/
https://www.ncbi.nlm.nih.gov/pubmed/32911592
http://dx.doi.org/10.12701/yujm.2020.00675
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