PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The purpose of this study was to develop a physiologically based pharmacokinetic (PBPK) model predicting the pharmacokinetics (PK) of different compounds in pregnant subjects. This model considers the differences in tissue sizes, blood flow rates, enzyme expression levels, glomerular filtration rate...

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Detalles Bibliográficos
Autores principales: Szeto, Ke Xu, Le Merdy, Maxime, Dupont, Benjamin, Bolger, Michael B., Lukacova, Viera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225528/
https://www.ncbi.nlm.nih.gov/pubmed/34169370
http://dx.doi.org/10.1208/s12248-021-00603-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225528/
https://www.ncbi.nlm.nih.gov/pubmed/34169370
http://dx.doi.org/10.1208/s12248-021-00603-y

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