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GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma

GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L a...

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Autores principales: Yu, Yilin, Wang, Zhiping, Zheng, Qunhao, Li, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225624/
https://www.ncbi.nlm.nih.gov/pubmed/34168239
http://dx.doi.org/10.1038/s41598-021-92695-x
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author Yu, Yilin
Wang, Zhiping
Zheng, Qunhao
Li, Jiancheng
author_facet Yu, Yilin
Wang, Zhiping
Zheng, Qunhao
Li, Jiancheng
author_sort Yu, Yilin
collection PubMed
description GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, HPA, TIMER, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, GREB1L expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high GREB1L expression levels were correlated with a poor OS in LUAD. Additionally, GREB1L expression was independently associated with OS through a multivariate Cox analysis. GSEA analysis revealed enrichment in cell cycle, immune regulation, and methylation. Moreover, high GREB1L expression was associated with poor survival. We also found that the methylation and genetic alteration level was associated with prognosis in patients with LUAD. Finally, an analysis of immune infiltration showed that GREB1L is correlated with immune cell infiltration, PD-1, and PD-L1. In summary, these results indicate that GREB1L is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers.
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spelling pubmed-82256242021-07-02 GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma Yu, Yilin Wang, Zhiping Zheng, Qunhao Li, Jiancheng Sci Rep Article GREB1L is a protein-coding gene that is an important paralog of GREB1. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of GREB1L in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between GREB1L and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, HPA, TIMER, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, GREB1L expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high GREB1L expression levels were correlated with a poor OS in LUAD. Additionally, GREB1L expression was independently associated with OS through a multivariate Cox analysis. GSEA analysis revealed enrichment in cell cycle, immune regulation, and methylation. Moreover, high GREB1L expression was associated with poor survival. We also found that the methylation and genetic alteration level was associated with prognosis in patients with LUAD. Finally, an analysis of immune infiltration showed that GREB1L is correlated with immune cell infiltration, PD-1, and PD-L1. In summary, these results indicate that GREB1L is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers. Nature Publishing Group UK 2021-06-24 /pmc/articles/PMC8225624/ /pubmed/34168239 http://dx.doi.org/10.1038/s41598-021-92695-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yu, Yilin
Wang, Zhiping
Zheng, Qunhao
Li, Jiancheng
GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_full GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_fullStr GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_full_unstemmed GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_short GREB1L overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
title_sort greb1l overexpression correlates with prognosis and immune cell infiltration in lung adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225624/
https://www.ncbi.nlm.nih.gov/pubmed/34168239
http://dx.doi.org/10.1038/s41598-021-92695-x
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AT zhengqunhao greb1loverexpressioncorrelateswithprognosisandimmunecellinfiltrationinlungadenocarcinoma
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