Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy

We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations a...

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Autores principales: Wang, Dan, Zhang, Yu, Han, Juan, Li, Xiao, Chen, Xiaofeng, Qiu, Tianzhu, Chen, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225647/
https://www.ncbi.nlm.nih.gov/pubmed/34168233
http://dx.doi.org/10.1038/s41598-021-92656-4
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author Wang, Dan
Zhang, Yu
Han, Juan
Li, Xiao
Chen, Xiaofeng
Qiu, Tianzhu
Chen, Hua
author_facet Wang, Dan
Zhang, Yu
Han, Juan
Li, Xiao
Chen, Xiaofeng
Qiu, Tianzhu
Chen, Hua
author_sort Wang, Dan
collection PubMed
description We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice.
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spelling pubmed-82256472021-07-02 Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy Wang, Dan Zhang, Yu Han, Juan Li, Xiao Chen, Xiaofeng Qiu, Tianzhu Chen, Hua Sci Rep Article We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice. Nature Publishing Group UK 2021-06-24 /pmc/articles/PMC8225647/ /pubmed/34168233 http://dx.doi.org/10.1038/s41598-021-92656-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Dan
Zhang, Yu
Han, Juan
Li, Xiao
Chen, Xiaofeng
Qiu, Tianzhu
Chen, Hua
Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_full Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_fullStr Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_full_unstemmed Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_short Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_sort quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225647/
https://www.ncbi.nlm.nih.gov/pubmed/34168233
http://dx.doi.org/10.1038/s41598-021-92656-4
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