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Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

Additional sex combs-like 1 (ASXL1) interacts with BRCA1-associated protein 1 (BAP1) deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone H2A ubiquitylation. Germline BAP1 mutations are found in a spectrum of human malignancies, while ASXL1 mutations recurrently occur i...

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Detalles Bibliográficos
Autores principales:	Xia, Yu-Kun, Zeng, Yi-Rong, Zhang, Meng-Li, Liu, Peng, Liu, Fang, Zhang, Hao, He, Chen-Xi, Sun, Yi-Ping, Zhang, Jin-Ye, Zhang, Cheng, Song, Lei, Ding, Chen, Tang, Yu-Jie, Yang, Zhen, Yang, Chen, Wang, Pu, Guan, Kun-Liang, Xiong, Yue, Ye, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225741/ https://www.ncbi.nlm.nih.gov/pubmed/32683582 http://dx.doi.org/10.1007/s13238-020-00754-2

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