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Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess...

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Autores principales: He, Li, Wang, Pin, Schick, Suzyann F., Huang, Abel, Jacob, Peyton, Yang, Xu, Xia, Yankai, Snijders, Antoine M., Mao, Jian-Hua, Chang, Hang, Hang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225773/
https://www.ncbi.nlm.nih.gov/pubmed/34168244
http://dx.doi.org/10.1038/s41598-021-92702-1
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author He, Li
Wang, Pin
Schick, Suzyann F.
Huang, Abel
Jacob, Peyton
Yang, Xu
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
Chang, Hang
Hang, Bo
author_facet He, Li
Wang, Pin
Schick, Suzyann F.
Huang, Abel
Jacob, Peyton
Yang, Xu
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
Chang, Hang
Hang, Bo
author_sort He, Li
collection PubMed
description Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects.
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spelling pubmed-82257732021-07-02 Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice He, Li Wang, Pin Schick, Suzyann F. Huang, Abel Jacob, Peyton Yang, Xu Xia, Yankai Snijders, Antoine M. Mao, Jian-Hua Chang, Hang Hang, Bo Sci Rep Article Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects. Nature Publishing Group UK 2021-06-24 /pmc/articles/PMC8225773/ /pubmed/34168244 http://dx.doi.org/10.1038/s41598-021-92702-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Li
Wang, Pin
Schick, Suzyann F.
Huang, Abel
Jacob, Peyton
Yang, Xu
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
Chang, Hang
Hang, Bo
Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_full Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_fullStr Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_full_unstemmed Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_short Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
title_sort genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in collaborative cross mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225773/
https://www.ncbi.nlm.nih.gov/pubmed/34168244
http://dx.doi.org/10.1038/s41598-021-92702-1
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