Cargando…

Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance

Studying the biomechanical properties of biological tissue is crucial to improve our understanding of disease pathogenesis. The biomechanical characteristics of the cornea, sclera and the optic nerve head have been well addressed with an extensive literature and an in-depth understanding of their si...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferrara, Mariantonia, Lugano, Gaia, Sandinha, Maria Teresa, Kearns, Victoria R., Geraghty, Brendan, Steel, David H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225810/
https://www.ncbi.nlm.nih.gov/pubmed/33649576
http://dx.doi.org/10.1038/s41433-021-01437-w
_version_ 1783712150893625344
author Ferrara, Mariantonia
Lugano, Gaia
Sandinha, Maria Teresa
Kearns, Victoria R.
Geraghty, Brendan
Steel, David H. W.
author_facet Ferrara, Mariantonia
Lugano, Gaia
Sandinha, Maria Teresa
Kearns, Victoria R.
Geraghty, Brendan
Steel, David H. W.
author_sort Ferrara, Mariantonia
collection PubMed
description Studying the biomechanical properties of biological tissue is crucial to improve our understanding of disease pathogenesis. The biomechanical characteristics of the cornea, sclera and the optic nerve head have been well addressed with an extensive literature and an in-depth understanding of their significance whilst, in comparison, knowledge of the retina and choroid is relatively limited. Knowledge of these tissues is important not only to clarify the underlying pathogenesis of a wide variety of retinal and vitreoretinal diseases, including age-related macular degeneration, hereditary retinal dystrophies and vitreoretinal interface diseases but also to optimise the surgical handling of retinal tissues and, potentially, the design and properties of implantable retinal prostheses and subretinal therapies. Our aim with this article is to comprehensively review existing knowledge of the biomechanical properties of retina, internal limiting membrane (ILM) and the Bruch’s membrane–choroidal complex (BMCC), highlighting the potential implications for clinical and surgical practice. Prior to this we review the testing methodologies that have been used both in vitro, and those starting to be used in vivo to aid understanding of their results and significance.
format Online
Article
Text
id pubmed-8225810
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-82258102021-07-09 Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance Ferrara, Mariantonia Lugano, Gaia Sandinha, Maria Teresa Kearns, Victoria R. Geraghty, Brendan Steel, David H. W. Eye (Lond) Review Article Studying the biomechanical properties of biological tissue is crucial to improve our understanding of disease pathogenesis. The biomechanical characteristics of the cornea, sclera and the optic nerve head have been well addressed with an extensive literature and an in-depth understanding of their significance whilst, in comparison, knowledge of the retina and choroid is relatively limited. Knowledge of these tissues is important not only to clarify the underlying pathogenesis of a wide variety of retinal and vitreoretinal diseases, including age-related macular degeneration, hereditary retinal dystrophies and vitreoretinal interface diseases but also to optimise the surgical handling of retinal tissues and, potentially, the design and properties of implantable retinal prostheses and subretinal therapies. Our aim with this article is to comprehensively review existing knowledge of the biomechanical properties of retina, internal limiting membrane (ILM) and the Bruch’s membrane–choroidal complex (BMCC), highlighting the potential implications for clinical and surgical practice. Prior to this we review the testing methodologies that have been used both in vitro, and those starting to be used in vivo to aid understanding of their results and significance. Nature Publishing Group UK 2021-03-01 2021-07 /pmc/articles/PMC8225810/ /pubmed/33649576 http://dx.doi.org/10.1038/s41433-021-01437-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ferrara, Mariantonia
Lugano, Gaia
Sandinha, Maria Teresa
Kearns, Victoria R.
Geraghty, Brendan
Steel, David H. W.
Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title_full Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title_fullStr Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title_full_unstemmed Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title_short Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
title_sort biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225810/
https://www.ncbi.nlm.nih.gov/pubmed/33649576
http://dx.doi.org/10.1038/s41433-021-01437-w
work_keys_str_mv AT ferraramariantonia biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance
AT luganogaia biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance
AT sandinhamariateresa biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance
AT kearnsvictoriar biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance
AT geraghtybrendan biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance
AT steeldavidhw biomechanicalpropertiesofretinaandchoroidacomprehensivereviewoftechniquesandtranslationalrelevance