Cargando…

Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19

Although macrophages are recognized as important players in the pathogenesis of chronic liver diseases, their roles in cholestatic liver fibrosis remain incompletely understood. We previously reported that long noncoding RNA-H19 (lncRNA-H19) contributes to cholangiocyte proliferation and cholestatic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Xinbei, Wang, Ying, Lu, Ying, Wang, Weipeng, Du, Jun, Chen, Shanshan, Zhou, Huiping, Cai, Wei, Xiao, Yongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225916/ https://www.ncbi.nlm.nih.gov/pubmed/34168124 http://dx.doi.org/10.1038/s41419-021-03931-1

Ejemplares similares

Upregulation of cadherin‐11 contributes to cholestatic liver fibrosis
por: Wu, Bo, et al.
Publicado: (2022)

Metabolic regulation of cholestatic liver injury by D-2-hydroxyglutarate with the modulation of hepatic microenvironment and the mammalian target of rapamycin signaling
por: Tian, Xinbei, et al.
Publicado: (2022)

Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions
por: Li, Xiaojiaoyang, et al.
Publicado: (2020)

Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis
por: Wan, Xiaoyu, et al.
Publicado: (2020)

Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway
por: Wang, Weipeng, et al.
Publicado: (2023)

Beta-amyloid Deposition in Biliary Atresia Reduces Liver Regeneration by Inhibiting Energy Metabolism and Mammalian Target of Rapamycin Signaling
por: Tian, Xinbei, et al.
Publicado: (2022)

Inhibition of CBP/β‐catenin signaling ameliorated fibrosis in cholestatic liver disease
por: Kimura, Masamichi, et al.
Publicado: (2022)

GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer
por: Zhang, Qunchang, et al.
Publicado: (2019)

Loss of lncRNA MIAT ameliorates proliferation and fibrosis of diabetic nephropathy through reducing E2F3 expression
por: Ji, Ting‐Ting, et al.
Publicado: (2020)

PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver
por: Xiao, Yongtao, et al.
Publicado: (2018)

The roles of lncRNA in hepatic fibrosis
por: Peng, Hu, et al.
Publicado: (2018)

Fibrosis in Autoimmune and Cholestatic Liver Disease
por: Penz-Österreicher, Melitta, et al.
Publicado: (2011)

Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis
por: Li, Zhongxian, et al.
Publicado: (2023)

Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis
por: Zhang, Kun, et al.
Publicado: (2020)

Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis
por: Song, Xiaodong, et al.
Publicado: (2014)

The role of bile acids in cholestatic liver injury
por: Cai, Shi-Ying, et al.
Publicado: (2021)

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis
por: Gong, Zizhen, et al.
Publicado: (2016)

Bile acid-mediated signaling in cholestatic liver diseases
por: Zeng, Jing, et al.
Publicado: (2023)

Depletion of lncRNA MEG3 Ameliorates Imatinib-Induced Injury of Cardiomyocytes via Regulating miR-129-5p/HMGB1 Axis
por: Tang, Peng, et al.
Publicado: (2023)

lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases
por: Nie, Lulingxiao, et al.
Publicado: (2019)

Tamoxifen Ameliorates Cholestatic Liver Fibrosis in Mice: Upregulation of TGFβ and IL6 Is a Potential Protective Mechanism
por: Šisl, Dino, et al.
Publicado: (2022)

LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes
por: Sun, Fei, et al.
Publicado: (2019)

Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis
por: Qi, Wenchuan, et al.
Publicado: (2022)

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model
por: Ceci, Ludovica, et al.
Publicado: (2022)

Integrated Analysis of lncRNA-Associated ceRNA Network Identifies Two lncRNA Signatures as a Prognostic Biomarker in Gastric Cancer
por: Zhang, Shuyan, et al.
Publicado: (2021)

The lncRNA Neat1 promotes activation of inflammasomes in macrophages
por: Zhang, Pengfei, et al.
Publicado: (2019)

dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
por: Zhang, Ying-Ying, et al.
Publicado: (2022)

LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression
por: Tang, Philip Chiu-Tsun, et al.
Publicado: (2022)

Aging-Related Molecular Pathways in Chronic Cholestatic Conditions
por: Pinto, Claudio, et al.
Publicado: (2020)

Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus
por: Zhang, Chuan-Ling, et al.
Publicado: (2021)

lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization
por: Zhao, Kunming, et al.
Publicado: (2022)

SGII: Systematic Identification of Essential lncRNAs in Mouse and Human Genome With lncRNA-Protein-Protein Heterogeneous Interaction Network
por: Xin, Xiao-Hong, et al.
Publicado: (2022)

Intestinal Reg4 deficiency confers susceptibility to high-fat diet-induced liver steatosis by increasing intestinal fat absorption in mice
por: Wang, Ying, et al.
Publicado: (2023)

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
por: Gui, Wenfang, et al.
Publicado: (2023)

LET's sponge: How the lncRNA PFL promotes cardiac fibrosis
por: Leisegang, Matthias S.
Publicado: (2018)

ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis
por: Hao, Lihua, et al.
Publicado: (2020)

The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis
por: Fuji, Hiroaki, et al.
Publicado: (2021)

Human lncRNA SUGCT-AS1 Regulates the Proinflammatory Response of Macrophage
por: Lim, Yeong-Hwan, et al.
Publicado: (2023)

Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis
por: Huang, Lei, et al.
Publicado: (2018)

Functions of lncRNA HOTAIR in lung cancer
por: Loewen, Gregory, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fo082uh37kfh29qihmi4m7emgr