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Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome
BACKGROUND AND PURPOSE: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. CASE REPORT: Herein, we report a four– year- old female who was admitted to th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Medical Mycology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226046/ https://www.ncbi.nlm.nih.gov/pubmed/34195464 http://dx.doi.org/10.18502/cmm.6.4.5441 |
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author | Fattahi, Azam Sayyahfar, Shirin Lotfali, Ensieh Ghasemi, Reza Mortezaeian, Hojjat |
author_facet | Fattahi, Azam Sayyahfar, Shirin Lotfali, Ensieh Ghasemi, Reza Mortezaeian, Hojjat |
author_sort | Fattahi, Azam |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. CASE REPORT: Herein, we report a four– year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. She was a known case of Marfan syndrome with a family history of this syndrome in her mother. The species was identified using (PCR) and the antifungal susceptibility test was performed using four antifungal agents based on the Clinical and Laboratory Standards Institute M38 3rd edition. Fluconazole-resistant Aspergillus flavus was identified to be responsible for endocarditis and meningitis as well as fever of unknown origin. CONCLUSION: The clinicians should be aware and consider fungal endocarditis in blood culture-negative endocarditis even in patients with no significant risk factor when antibiotic therapy fails. |
format | Online Article Text |
id | pubmed-8226046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Iranian Society of Medical Mycology |
record_format | MEDLINE/PubMed |
spelling | pubmed-82260462021-06-29 Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome Fattahi, Azam Sayyahfar, Shirin Lotfali, Ensieh Ghasemi, Reza Mortezaeian, Hojjat Curr Med Mycol Case Report BACKGROUND AND PURPOSE: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. CASE REPORT: Herein, we report a four– year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. She was a known case of Marfan syndrome with a family history of this syndrome in her mother. The species was identified using (PCR) and the antifungal susceptibility test was performed using four antifungal agents based on the Clinical and Laboratory Standards Institute M38 3rd edition. Fluconazole-resistant Aspergillus flavus was identified to be responsible for endocarditis and meningitis as well as fever of unknown origin. CONCLUSION: The clinicians should be aware and consider fungal endocarditis in blood culture-negative endocarditis even in patients with no significant risk factor when antibiotic therapy fails. Iranian Society of Medical Mycology 2020-12 /pmc/articles/PMC8226046/ /pubmed/34195464 http://dx.doi.org/10.18502/cmm.6.4.5441 Text en Copyright: © 2020, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Fattahi, Azam Sayyahfar, Shirin Lotfali, Ensieh Ghasemi, Reza Mortezaeian, Hojjat Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title | Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_full | Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_fullStr | Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_full_unstemmed | Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_short | Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
title_sort | aspergillus flavus endocarditis and meningitis in a child with marfan syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226046/ https://www.ncbi.nlm.nih.gov/pubmed/34195464 http://dx.doi.org/10.18502/cmm.6.4.5441 |
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