Cargando…
Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research
We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for targeting the host de novo purine synthetic pathw...
Autor principal: | Mazzarino, Randall C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226072/ https://www.ncbi.nlm.nih.gov/pubmed/34177959 http://dx.doi.org/10.3389/fimmu.2021.694300 |
Ejemplares similares
-
Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity
por: Mazzarino, Randall C., et al.
Publicado: (2021) -
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
por: Souckova, Olga, et al.
Publicado: (2022) -
Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis
por: Mádrová, Lucie, et al.
Publicado: (2022) -
Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
por: Mizukoshi, Tomoya, et al.
Publicado: (2023) -
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions
por: Zhang, Pu, et al.
Publicado: (2022)