Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

BACKGROUND: Mutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular including vitamin A metabolism and retinoic acid receptor beta (RARβ) expression. The goal of the present study was to investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelwahab, Elhusseiny Mohamed Mahmoud, Bovari-Biri, Judit, Smuk, Gabor, Harko, Tunde, Fillinger, Janos, Moldvay, Judit, Krymskaya, Vera P., Pongracz, Judit E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226169/
https://www.ncbi.nlm.nih.gov/pubmed/34178631
http://dx.doi.org/10.3389/fonc.2021.644592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226169/
https://www.ncbi.nlm.nih.gov/pubmed/34178631
http://dx.doi.org/10.3389/fonc.2021.644592

Ejemplares similares