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Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

BACKGROUND: Mutation in a tuberous sclerosis gene (TSC1 or 2) leads to continuous activation of the mammalian target of rapamycin (mTOR). mTOR activation alters cellular including vitamin A metabolism and retinoic acid receptor beta (RARβ) expression. The goal of the present study was to investigate...

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Detalles Bibliográficos
Autores principales:	Abdelwahab, Elhusseiny Mohamed Mahmoud, Bovari-Biri, Judit, Smuk, Gabor, Harko, Tunde, Fillinger, Janos, Moldvay, Judit, Krymskaya, Vera P., Pongracz, Judit E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226169/ https://www.ncbi.nlm.nih.gov/pubmed/34178631 http://dx.doi.org/10.3389/fonc.2021.644592

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