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Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226213/ https://www.ncbi.nlm.nih.gov/pubmed/34178033 http://dx.doi.org/10.3389/fgene.2021.671467 |
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author | Babić Jordamović, Naida Kojović, Tamara Dogan, Serkan Bešić, Larisa Salihefendić, Lana Konjhodžić, Rijad Škaro, Vedrana Projić, Petar Hadžiavdić, Vesna Ašić, Adna Marjanović, Damir |
author_facet | Babić Jordamović, Naida Kojović, Tamara Dogan, Serkan Bešić, Larisa Salihefendić, Lana Konjhodžić, Rijad Škaro, Vedrana Projić, Petar Hadžiavdić, Vesna Ašić, Adna Marjanović, Damir |
author_sort | Babić Jordamović, Naida |
collection | PubMed |
description | Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers. Y chromosome haplogroups can be successfully predicted from Y-short tandem repeat (STR) markers using different software packages, and this method gained much attention recently due to its labor-, time-, and cost-effectiveness. The present study was based on the analysis of a total of 480 adult male buccal swab samples collected from different regions of Bosnia and Herzegovina. Y haplogroup prediction was performed using Whit Athey’s Haplogroup Predictor, based on haplotype data on 23 Y-STR markers contained within the PowerPlex® Y23 kit. The results revealed the existence of 14 different haplogroups, with I2a, R1a, and E1b1b being the most prevalent with frequencies of 43.13, 14.79, and 14.58%, respectively. Compared to the previously published studies on Bosnian-Herzegovinian population based on Y-SNP and Y-STR data, this study represents an upgrade of molecular genetic data with a significantly larger number of samples, thus offering more accurate results and higher probability of detecting rare haplogroups. |
format | Online Article Text |
id | pubmed-8226213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82262132021-06-26 Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina Babić Jordamović, Naida Kojović, Tamara Dogan, Serkan Bešić, Larisa Salihefendić, Lana Konjhodžić, Rijad Škaro, Vedrana Projić, Petar Hadžiavdić, Vesna Ašić, Adna Marjanović, Damir Front Genet Genetics Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers. Y chromosome haplogroups can be successfully predicted from Y-short tandem repeat (STR) markers using different software packages, and this method gained much attention recently due to its labor-, time-, and cost-effectiveness. The present study was based on the analysis of a total of 480 adult male buccal swab samples collected from different regions of Bosnia and Herzegovina. Y haplogroup prediction was performed using Whit Athey’s Haplogroup Predictor, based on haplotype data on 23 Y-STR markers contained within the PowerPlex® Y23 kit. The results revealed the existence of 14 different haplogroups, with I2a, R1a, and E1b1b being the most prevalent with frequencies of 43.13, 14.79, and 14.58%, respectively. Compared to the previously published studies on Bosnian-Herzegovinian population based on Y-SNP and Y-STR data, this study represents an upgrade of molecular genetic data with a significantly larger number of samples, thus offering more accurate results and higher probability of detecting rare haplogroups. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8226213/ /pubmed/34178033 http://dx.doi.org/10.3389/fgene.2021.671467 Text en Copyright © 2021 Babić Jordamović, Kojović, Dogan, Bešić, Salihefendić, Konjhodžić, Škaro, Projić, Hadžiavdić, Ašić and Marjanović. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Babić Jordamović, Naida Kojović, Tamara Dogan, Serkan Bešić, Larisa Salihefendić, Lana Konjhodžić, Rijad Škaro, Vedrana Projić, Petar Hadžiavdić, Vesna Ašić, Adna Marjanović, Damir Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title | Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title_full | Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title_fullStr | Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title_full_unstemmed | Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title_short | Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina |
title_sort | haplogroup prediction using y-chromosomal short tandem repeats in the general population of bosnia and herzegovina |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226213/ https://www.ncbi.nlm.nih.gov/pubmed/34178033 http://dx.doi.org/10.3389/fgene.2021.671467 |
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