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Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina

Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers....

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Autores principales: Babić Jordamović, Naida, Kojović, Tamara, Dogan, Serkan, Bešić, Larisa, Salihefendić, Lana, Konjhodžić, Rijad, Škaro, Vedrana, Projić, Petar, Hadžiavdić, Vesna, Ašić, Adna, Marjanović, Damir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226213/
https://www.ncbi.nlm.nih.gov/pubmed/34178033
http://dx.doi.org/10.3389/fgene.2021.671467
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author Babić Jordamović, Naida
Kojović, Tamara
Dogan, Serkan
Bešić, Larisa
Salihefendić, Lana
Konjhodžić, Rijad
Škaro, Vedrana
Projić, Petar
Hadžiavdić, Vesna
Ašić, Adna
Marjanović, Damir
author_facet Babić Jordamović, Naida
Kojović, Tamara
Dogan, Serkan
Bešić, Larisa
Salihefendić, Lana
Konjhodžić, Rijad
Škaro, Vedrana
Projić, Petar
Hadžiavdić, Vesna
Ašić, Adna
Marjanović, Damir
author_sort Babić Jordamović, Naida
collection PubMed
description Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers. Y chromosome haplogroups can be successfully predicted from Y-short tandem repeat (STR) markers using different software packages, and this method gained much attention recently due to its labor-, time-, and cost-effectiveness. The present study was based on the analysis of a total of 480 adult male buccal swab samples collected from different regions of Bosnia and Herzegovina. Y haplogroup prediction was performed using Whit Athey’s Haplogroup Predictor, based on haplotype data on 23 Y-STR markers contained within the PowerPlex® Y23 kit. The results revealed the existence of 14 different haplogroups, with I2a, R1a, and E1b1b being the most prevalent with frequencies of 43.13, 14.79, and 14.58%, respectively. Compared to the previously published studies on Bosnian-Herzegovinian population based on Y-SNP and Y-STR data, this study represents an upgrade of molecular genetic data with a significantly larger number of samples, thus offering more accurate results and higher probability of detecting rare haplogroups.
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spelling pubmed-82262132021-06-26 Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina Babić Jordamović, Naida Kojović, Tamara Dogan, Serkan Bešić, Larisa Salihefendić, Lana Konjhodžić, Rijad Škaro, Vedrana Projić, Petar Hadžiavdić, Vesna Ašić, Adna Marjanović, Damir Front Genet Genetics Human Y-chromosomal haplogroups are an important tool used in population genetics and forensic genetics. A conventional method used for Y haplogroup assignment is based on a set of Y-single nucleotide polymorphism (SNP) markers deployed, which exploits the low mutation rate nature of these markers. Y chromosome haplogroups can be successfully predicted from Y-short tandem repeat (STR) markers using different software packages, and this method gained much attention recently due to its labor-, time-, and cost-effectiveness. The present study was based on the analysis of a total of 480 adult male buccal swab samples collected from different regions of Bosnia and Herzegovina. Y haplogroup prediction was performed using Whit Athey’s Haplogroup Predictor, based on haplotype data on 23 Y-STR markers contained within the PowerPlex® Y23 kit. The results revealed the existence of 14 different haplogroups, with I2a, R1a, and E1b1b being the most prevalent with frequencies of 43.13, 14.79, and 14.58%, respectively. Compared to the previously published studies on Bosnian-Herzegovinian population based on Y-SNP and Y-STR data, this study represents an upgrade of molecular genetic data with a significantly larger number of samples, thus offering more accurate results and higher probability of detecting rare haplogroups. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8226213/ /pubmed/34178033 http://dx.doi.org/10.3389/fgene.2021.671467 Text en Copyright © 2021 Babić Jordamović, Kojović, Dogan, Bešić, Salihefendić, Konjhodžić, Škaro, Projić, Hadžiavdić, Ašić and Marjanović. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Babić Jordamović, Naida
Kojović, Tamara
Dogan, Serkan
Bešić, Larisa
Salihefendić, Lana
Konjhodžić, Rijad
Škaro, Vedrana
Projić, Petar
Hadžiavdić, Vesna
Ašić, Adna
Marjanović, Damir
Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title_full Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title_fullStr Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title_full_unstemmed Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title_short Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina
title_sort haplogroup prediction using y-chromosomal short tandem repeats in the general population of bosnia and herzegovina
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226213/
https://www.ncbi.nlm.nih.gov/pubmed/34178033
http://dx.doi.org/10.3389/fgene.2021.671467
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