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Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury

We describe a case of Lichtenberg Figures (LFs) following an electrical injury from a high-voltage switchgear in a 47 year-old electrician. LFs, also known as ferning pattern or keraunographic markings, are a pathognomonic skin sign for lightning strike injuries. Their true pathophysiology has remai...

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Autores principales: Lindford, Andrew, Juteau, Susanna, Jaks, Viljar, Klaas, Mariliis, Lagus, Heli, Vuola, Jyrki, Kankuri, Esko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226253/
https://www.ncbi.nlm.nih.gov/pubmed/34179045
http://dx.doi.org/10.3389/fmed.2021.663807
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author Lindford, Andrew
Juteau, Susanna
Jaks, Viljar
Klaas, Mariliis
Lagus, Heli
Vuola, Jyrki
Kankuri, Esko
author_facet Lindford, Andrew
Juteau, Susanna
Jaks, Viljar
Klaas, Mariliis
Lagus, Heli
Vuola, Jyrki
Kankuri, Esko
author_sort Lindford, Andrew
collection PubMed
description We describe a case of Lichtenberg Figures (LFs) following an electrical injury from a high-voltage switchgear in a 47 year-old electrician. LFs, also known as ferning pattern or keraunographic markings, are a pathognomonic skin sign for lightning strike injuries. Their true pathophysiology has remained a mystery and only once before described following an electical injury. The aim was to characterise the tissue response of LFs by performing untargeted non-labelled proteomics and immunohistochemistry on paraffin-embedded sections of skin biopsies taken from the area of LFs at presentation and at 3 months follow-up. Our results demonstrated an increase in dermal T-cells and greatly increased expression of the iron-binding glycoprotein lactoferrin by keratinocytes and lymphocytes. These changes in the LF-affected skin were associated with extravasation of red blood cells from dermal vessels. Our results provide an initial molecular and cellular insight into the tissue response associated with LFs.
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spelling pubmed-82262532021-06-26 Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury Lindford, Andrew Juteau, Susanna Jaks, Viljar Klaas, Mariliis Lagus, Heli Vuola, Jyrki Kankuri, Esko Front Med (Lausanne) Medicine We describe a case of Lichtenberg Figures (LFs) following an electrical injury from a high-voltage switchgear in a 47 year-old electrician. LFs, also known as ferning pattern or keraunographic markings, are a pathognomonic skin sign for lightning strike injuries. Their true pathophysiology has remained a mystery and only once before described following an electical injury. The aim was to characterise the tissue response of LFs by performing untargeted non-labelled proteomics and immunohistochemistry on paraffin-embedded sections of skin biopsies taken from the area of LFs at presentation and at 3 months follow-up. Our results demonstrated an increase in dermal T-cells and greatly increased expression of the iron-binding glycoprotein lactoferrin by keratinocytes and lymphocytes. These changes in the LF-affected skin were associated with extravasation of red blood cells from dermal vessels. Our results provide an initial molecular and cellular insight into the tissue response associated with LFs. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8226253/ /pubmed/34179045 http://dx.doi.org/10.3389/fmed.2021.663807 Text en Copyright © 2021 Lindford, Juteau, Jaks, Klaas, Lagus, Vuola and Kankuri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lindford, Andrew
Juteau, Susanna
Jaks, Viljar
Klaas, Mariliis
Lagus, Heli
Vuola, Jyrki
Kankuri, Esko
Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title_full Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title_fullStr Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title_full_unstemmed Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title_short Case Report: Unravelling the Mysterious Lichtenberg Figure Skin Response in a Patient With a High-Voltage Electrical Injury
title_sort case report: unravelling the mysterious lichtenberg figure skin response in a patient with a high-voltage electrical injury
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226253/
https://www.ncbi.nlm.nih.gov/pubmed/34179045
http://dx.doi.org/10.3389/fmed.2021.663807
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