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Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features

(1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examin...

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Autores principales: Tipaldi, Marcello Andrea, Ronconi, Edoardo, Lucertini, Elena, Krokidis, Miltiadis, Zerunian, Marta, Polidori, Tiziano, Begini, Paola, Marignani, Massimo, Mazzuca, Federica, Caruso, Damiano, Rossi, Michele, Laghi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226518/
https://www.ncbi.nlm.nih.gov/pubmed/34073545
http://dx.doi.org/10.3390/diagnostics11060956
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author Tipaldi, Marcello Andrea
Ronconi, Edoardo
Lucertini, Elena
Krokidis, Miltiadis
Zerunian, Marta
Polidori, Tiziano
Begini, Paola
Marignani, Massimo
Mazzuca, Federica
Caruso, Damiano
Rossi, Michele
Laghi, Andrea
author_facet Tipaldi, Marcello Andrea
Ronconi, Edoardo
Lucertini, Elena
Krokidis, Miltiadis
Zerunian, Marta
Polidori, Tiziano
Begini, Paola
Marignani, Massimo
Mazzuca, Federica
Caruso, Damiano
Rossi, Michele
Laghi, Andrea
author_sort Tipaldi, Marcello Andrea
collection PubMed
description (1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all p < 0.001). A predictive model to identify patients with a high and low probability of CR was evaluated with an ROC curve, with an AUC of 0.733 (p < 0.001). The three models built for survival prediction yielded an HR of 2.19 (95% CI: 2.03–2.35) using texture features, of 1.7 (95% CI: 1.54–1.9) using clinical data and of 4.61 (95% CI: 4.24–5.01) combining both radiomics and clinical data (all p < 0.0001). (4) Conclusion: Texture analysis based on pre-treatment CT examination is associated with response to therapy and survival in patients with HCC undergoing DEB-TACE, especially if combined with clinical data.
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spelling pubmed-82265182021-06-26 Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features Tipaldi, Marcello Andrea Ronconi, Edoardo Lucertini, Elena Krokidis, Miltiadis Zerunian, Marta Polidori, Tiziano Begini, Paola Marignani, Massimo Mazzuca, Federica Caruso, Damiano Rossi, Michele Laghi, Andrea Diagnostics (Basel) Article (1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all p < 0.001). A predictive model to identify patients with a high and low probability of CR was evaluated with an ROC curve, with an AUC of 0.733 (p < 0.001). The three models built for survival prediction yielded an HR of 2.19 (95% CI: 2.03–2.35) using texture features, of 1.7 (95% CI: 1.54–1.9) using clinical data and of 4.61 (95% CI: 4.24–5.01) combining both radiomics and clinical data (all p < 0.0001). (4) Conclusion: Texture analysis based on pre-treatment CT examination is associated with response to therapy and survival in patients with HCC undergoing DEB-TACE, especially if combined with clinical data. MDPI 2021-05-26 /pmc/articles/PMC8226518/ /pubmed/34073545 http://dx.doi.org/10.3390/diagnostics11060956 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tipaldi, Marcello Andrea
Ronconi, Edoardo
Lucertini, Elena
Krokidis, Miltiadis
Zerunian, Marta
Polidori, Tiziano
Begini, Paola
Marignani, Massimo
Mazzuca, Federica
Caruso, Damiano
Rossi, Michele
Laghi, Andrea
Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title_full Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title_fullStr Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title_full_unstemmed Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title_short Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features
title_sort hepatocellular carcinoma drug-eluting bead transarterial chemoembolization (deb-tace): outcome analysis using a model based on pre-treatment ct texture features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226518/
https://www.ncbi.nlm.nih.gov/pubmed/34073545
http://dx.doi.org/10.3390/diagnostics11060956
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