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Sarcoma Metabolomics: Current Horizons and Future Perspectives
The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism r...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226523/ https://www.ncbi.nlm.nih.gov/pubmed/34201149 http://dx.doi.org/10.3390/cells10061432 |
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author | Esperança-Martins, Miguel Fernandes, Isabel Soares do Brito, Joaquim Macedo, Daniela Vasques, Hugo Serafim, Teresa Costa, Luís Dias, Sérgio |
author_facet | Esperança-Martins, Miguel Fernandes, Isabel Soares do Brito, Joaquim Macedo, Daniela Vasques, Hugo Serafim, Teresa Costa, Luís Dias, Sérgio |
author_sort | Esperança-Martins, Miguel |
collection | PubMed |
description | The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics. |
format | Online Article Text |
id | pubmed-8226523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82265232021-06-26 Sarcoma Metabolomics: Current Horizons and Future Perspectives Esperança-Martins, Miguel Fernandes, Isabel Soares do Brito, Joaquim Macedo, Daniela Vasques, Hugo Serafim, Teresa Costa, Luís Dias, Sérgio Cells Review The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics. MDPI 2021-06-08 /pmc/articles/PMC8226523/ /pubmed/34201149 http://dx.doi.org/10.3390/cells10061432 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Esperança-Martins, Miguel Fernandes, Isabel Soares do Brito, Joaquim Macedo, Daniela Vasques, Hugo Serafim, Teresa Costa, Luís Dias, Sérgio Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title_full | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title_fullStr | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title_full_unstemmed | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title_short | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
title_sort | sarcoma metabolomics: current horizons and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226523/ https://www.ncbi.nlm.nih.gov/pubmed/34201149 http://dx.doi.org/10.3390/cells10061432 |
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