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Sarcoma Metabolomics: Current Horizons and Future Perspectives

The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism r...

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Autores principales: Esperança-Martins, Miguel, Fernandes, Isabel, Soares do Brito, Joaquim, Macedo, Daniela, Vasques, Hugo, Serafim, Teresa, Costa, Luís, Dias, Sérgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226523/
https://www.ncbi.nlm.nih.gov/pubmed/34201149
http://dx.doi.org/10.3390/cells10061432
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author Esperança-Martins, Miguel
Fernandes, Isabel
Soares do Brito, Joaquim
Macedo, Daniela
Vasques, Hugo
Serafim, Teresa
Costa, Luís
Dias, Sérgio
author_facet Esperança-Martins, Miguel
Fernandes, Isabel
Soares do Brito, Joaquim
Macedo, Daniela
Vasques, Hugo
Serafim, Teresa
Costa, Luís
Dias, Sérgio
author_sort Esperança-Martins, Miguel
collection PubMed
description The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.
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spelling pubmed-82265232021-06-26 Sarcoma Metabolomics: Current Horizons and Future Perspectives Esperança-Martins, Miguel Fernandes, Isabel Soares do Brito, Joaquim Macedo, Daniela Vasques, Hugo Serafim, Teresa Costa, Luís Dias, Sérgio Cells Review The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics. MDPI 2021-06-08 /pmc/articles/PMC8226523/ /pubmed/34201149 http://dx.doi.org/10.3390/cells10061432 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Esperança-Martins, Miguel
Fernandes, Isabel
Soares do Brito, Joaquim
Macedo, Daniela
Vasques, Hugo
Serafim, Teresa
Costa, Luís
Dias, Sérgio
Sarcoma Metabolomics: Current Horizons and Future Perspectives
title Sarcoma Metabolomics: Current Horizons and Future Perspectives
title_full Sarcoma Metabolomics: Current Horizons and Future Perspectives
title_fullStr Sarcoma Metabolomics: Current Horizons and Future Perspectives
title_full_unstemmed Sarcoma Metabolomics: Current Horizons and Future Perspectives
title_short Sarcoma Metabolomics: Current Horizons and Future Perspectives
title_sort sarcoma metabolomics: current horizons and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226523/
https://www.ncbi.nlm.nih.gov/pubmed/34201149
http://dx.doi.org/10.3390/cells10061432
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