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Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little dat...

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Autores principales: Sharif, Hayfa, Hoad, Caroline L., Abrehart, Nichola, Gowland, Penny A., Spiller, Robin C., Kirkham, Sian, Loganathan, Sabarinathan, Papadopoulos, Michalis, Benninga, Marc A., Devadason, David, Marciani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226615/
https://www.ncbi.nlm.nih.gov/pubmed/34071217
http://dx.doi.org/10.3390/diagnostics11060974
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author Sharif, Hayfa
Hoad, Caroline L.
Abrehart, Nichola
Gowland, Penny A.
Spiller, Robin C.
Kirkham, Sian
Loganathan, Sabarinathan
Papadopoulos, Michalis
Benninga, Marc A.
Devadason, David
Marciani, Luca
author_facet Sharif, Hayfa
Hoad, Caroline L.
Abrehart, Nichola
Gowland, Penny A.
Spiller, Robin C.
Kirkham, Sian
Loganathan, Sabarinathan
Papadopoulos, Michalis
Benninga, Marc A.
Devadason, David
Marciani, Luca
author_sort Sharif, Hayfa
collection PubMed
description Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little data on paediatric colonic volume is available except from methods that are invasive or require unphysiological colonic preparations. Objectives: (1) To measure volumes of the undisturbed colon in children with functional constipation (FC) using magnetic resonance imaging (MRI) and provide initial normal range values for healthy controls, and (2) to investigate possible correlation of colonic volume with whole gut transit time (WGTT). Methods: Total and regional (ascending, transverse, descending, sigmoid, and rectum) colon volumes were measured from MRI images of 35 participants aged 7–18 years (16 with FC and 19 healthy controls), and corrected for body surface area. Linear regression was used to explore the relationship between total colon volume and WGTT. Results: Total colonic volume was significantly higher, with a median (interquartile range) of 309 mL (243–384 mL) for the FC group than for the healthy controls of 227 mL (180–263 mL). The largest increase between patients and controls was in the sigmoid colon–rectum region. In a linear regression model, there was a positive significant correlation between total colonic volume and WGTT (R = 0.56, p = 0.0005). Conclusions: This initial study shows increased volumes of the colon in children with FC, in a physiological state, without use of any bowel preparation. Increased knowledge of colonic morphology may improve understanding of FC in this age group and help to direct treatment.
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spelling pubmed-82266152021-06-26 Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI Sharif, Hayfa Hoad, Caroline L. Abrehart, Nichola Gowland, Penny A. Spiller, Robin C. Kirkham, Sian Loganathan, Sabarinathan Papadopoulos, Michalis Benninga, Marc A. Devadason, David Marciani, Luca Diagnostics (Basel) Article Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little data on paediatric colonic volume is available except from methods that are invasive or require unphysiological colonic preparations. Objectives: (1) To measure volumes of the undisturbed colon in children with functional constipation (FC) using magnetic resonance imaging (MRI) and provide initial normal range values for healthy controls, and (2) to investigate possible correlation of colonic volume with whole gut transit time (WGTT). Methods: Total and regional (ascending, transverse, descending, sigmoid, and rectum) colon volumes were measured from MRI images of 35 participants aged 7–18 years (16 with FC and 19 healthy controls), and corrected for body surface area. Linear regression was used to explore the relationship between total colon volume and WGTT. Results: Total colonic volume was significantly higher, with a median (interquartile range) of 309 mL (243–384 mL) for the FC group than for the healthy controls of 227 mL (180–263 mL). The largest increase between patients and controls was in the sigmoid colon–rectum region. In a linear regression model, there was a positive significant correlation between total colonic volume and WGTT (R = 0.56, p = 0.0005). Conclusions: This initial study shows increased volumes of the colon in children with FC, in a physiological state, without use of any bowel preparation. Increased knowledge of colonic morphology may improve understanding of FC in this age group and help to direct treatment. MDPI 2021-05-28 /pmc/articles/PMC8226615/ /pubmed/34071217 http://dx.doi.org/10.3390/diagnostics11060974 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sharif, Hayfa
Hoad, Caroline L.
Abrehart, Nichola
Gowland, Penny A.
Spiller, Robin C.
Kirkham, Sian
Loganathan, Sabarinathan
Papadopoulos, Michalis
Benninga, Marc A.
Devadason, David
Marciani, Luca
Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title_full Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title_fullStr Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title_full_unstemmed Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title_short Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI
title_sort colonic volume changes in paediatric constipation compared to normal values measured using mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226615/
https://www.ncbi.nlm.nih.gov/pubmed/34071217
http://dx.doi.org/10.3390/diagnostics11060974
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