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Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis

Vitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued...

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Autores principales: Catalano, Antonino, Bellone, Federica, Santoro, Domenico, Schwarz, Peter, Gaudio, Agostino, Basile, Giorgio, Sottile, Maria Carmela, Stoian, Sabrina Atena, Corica, Francesco, Morabito, Nunziata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226654/
https://www.ncbi.nlm.nih.gov/pubmed/34072655
http://dx.doi.org/10.3390/nu13061878
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author Catalano, Antonino
Bellone, Federica
Santoro, Domenico
Schwarz, Peter
Gaudio, Agostino
Basile, Giorgio
Sottile, Maria Carmela
Stoian, Sabrina Atena
Corica, Francesco
Morabito, Nunziata
author_facet Catalano, Antonino
Bellone, Federica
Santoro, Domenico
Schwarz, Peter
Gaudio, Agostino
Basile, Giorgio
Sottile, Maria Carmela
Stoian, Sabrina Atena
Corica, Francesco
Morabito, Nunziata
author_sort Catalano, Antonino
collection PubMed
description Vitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued the supplementation of cholecalciferol or calcifediol at recommended doses. In the ninety-six recruited women (age 61.1 ± 6.9 years), ALN was administered for 31.2 ± 20.6 months and then discontinued for 33.3 ± 18.9 months. The modification of 25(OH)D serum levels over time was associated with a change of alkaline phosphatase (r = −0.22, p = 0.018) and C-terminal collagen type 1 telopeptide (r = −0.3, p = 0.06). Women in the tertile of the highest increase in 25(OH)D level showed a 5.7% BMD gain at lumbar spine, that was twice as great in comparison with participants with a lower 25(OH)D variation. At a multiple regression analysis, BMD change was associated with time since menopause (ß = 2.28, SE 0.44, p < 0.0001), FRAX score for major fracture (ß = −0.65, SE 0.29, p = 0.03), drug holiday duration (ß = −2.17, SE 0.27, p < 0.0001) and change of 25(OH)D levels (ß = 0.15, SE 0.03, p = 0.0007). After ALN discontinuation, improving the vitamin D status boosts the ALN tail effect on BMD.
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spelling pubmed-82266542021-06-26 Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis Catalano, Antonino Bellone, Federica Santoro, Domenico Schwarz, Peter Gaudio, Agostino Basile, Giorgio Sottile, Maria Carmela Stoian, Sabrina Atena Corica, Francesco Morabito, Nunziata Nutrients Article Vitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued the supplementation of cholecalciferol or calcifediol at recommended doses. In the ninety-six recruited women (age 61.1 ± 6.9 years), ALN was administered for 31.2 ± 20.6 months and then discontinued for 33.3 ± 18.9 months. The modification of 25(OH)D serum levels over time was associated with a change of alkaline phosphatase (r = −0.22, p = 0.018) and C-terminal collagen type 1 telopeptide (r = −0.3, p = 0.06). Women in the tertile of the highest increase in 25(OH)D level showed a 5.7% BMD gain at lumbar spine, that was twice as great in comparison with participants with a lower 25(OH)D variation. At a multiple regression analysis, BMD change was associated with time since menopause (ß = 2.28, SE 0.44, p < 0.0001), FRAX score for major fracture (ß = −0.65, SE 0.29, p = 0.03), drug holiday duration (ß = −2.17, SE 0.27, p < 0.0001) and change of 25(OH)D levels (ß = 0.15, SE 0.03, p = 0.0007). After ALN discontinuation, improving the vitamin D status boosts the ALN tail effect on BMD. MDPI 2021-05-31 /pmc/articles/PMC8226654/ /pubmed/34072655 http://dx.doi.org/10.3390/nu13061878 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Catalano, Antonino
Bellone, Federica
Santoro, Domenico
Schwarz, Peter
Gaudio, Agostino
Basile, Giorgio
Sottile, Maria Carmela
Stoian, Sabrina Atena
Corica, Francesco
Morabito, Nunziata
Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title_full Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title_fullStr Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title_full_unstemmed Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title_short Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
title_sort vitamin d boosts alendronate tail effect on bone mineral density in postmenopausal women with osteoporosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226654/
https://www.ncbi.nlm.nih.gov/pubmed/34072655
http://dx.doi.org/10.3390/nu13061878
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