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The Hippo Pathway: A Master Regulatory Network Important in Cancer

The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significanc...

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Detalles Bibliográficos
Autores principales: Liu, Qiuping, Liu, Xiaomeng, Song, Guanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226666/
https://www.ncbi.nlm.nih.gov/pubmed/34200285
http://dx.doi.org/10.3390/cells10061416
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author Liu, Qiuping
Liu, Xiaomeng
Song, Guanbin
author_facet Liu, Qiuping
Liu, Xiaomeng
Song, Guanbin
author_sort Liu, Qiuping
collection PubMed
description The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significance and deregulation in cancer have drawn increasing interest in the past few years. A fundamental understanding of the complexity of the Hippo pathway in cancer is crucial for improving future clinical interventions and therapy for cancers. In this review, we try to clarify the complex regulation and function of the Hippo signaling network in cancer development, including its role in signal transduction, metabolic regulation, and tumor development, as well as tumor therapies targeting the Hippo pathway.
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spelling pubmed-82266662021-06-26 The Hippo Pathway: A Master Regulatory Network Important in Cancer Liu, Qiuping Liu, Xiaomeng Song, Guanbin Cells Review The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significance and deregulation in cancer have drawn increasing interest in the past few years. A fundamental understanding of the complexity of the Hippo pathway in cancer is crucial for improving future clinical interventions and therapy for cancers. In this review, we try to clarify the complex regulation and function of the Hippo signaling network in cancer development, including its role in signal transduction, metabolic regulation, and tumor development, as well as tumor therapies targeting the Hippo pathway. MDPI 2021-06-07 /pmc/articles/PMC8226666/ /pubmed/34200285 http://dx.doi.org/10.3390/cells10061416 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Qiuping
Liu, Xiaomeng
Song, Guanbin
The Hippo Pathway: A Master Regulatory Network Important in Cancer
title The Hippo Pathway: A Master Regulatory Network Important in Cancer
title_full The Hippo Pathway: A Master Regulatory Network Important in Cancer
title_fullStr The Hippo Pathway: A Master Regulatory Network Important in Cancer
title_full_unstemmed The Hippo Pathway: A Master Regulatory Network Important in Cancer
title_short The Hippo Pathway: A Master Regulatory Network Important in Cancer
title_sort hippo pathway: a master regulatory network important in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226666/
https://www.ncbi.nlm.nih.gov/pubmed/34200285
http://dx.doi.org/10.3390/cells10061416
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