An Orally Bioavailable (Mice) Prodrug of Glutathione

L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned...

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Detalles Bibliográficos
Autores principales: Crankshaw, Daune L., Briggs, Jacquie E., Vince, Robert, Nagasawa, Herbert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226670/
https://www.ncbi.nlm.nih.gov/pubmed/34200599
http://dx.doi.org/10.3390/antiox10060939
Descripción
Sumario:L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.

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