An Orally Bioavailable (Mice) Prodrug of Glutathione

L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned...

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Detalles Bibliográficos
Autores principales: Crankshaw, Daune L., Briggs, Jacquie E., Vince, Robert, Nagasawa, Herbert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226670/
https://www.ncbi.nlm.nih.gov/pubmed/34200599
http://dx.doi.org/10.3390/antiox10060939
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author Crankshaw, Daune L.
Briggs, Jacquie E.
Vince, Robert
Nagasawa, Herbert T.
author_facet Crankshaw, Daune L.
Briggs, Jacquie E.
Vince, Robert
Nagasawa, Herbert T.
author_sort Crankshaw, Daune L.
collection PubMed
description L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.
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spelling pubmed-82266702021-06-26 An Orally Bioavailable (Mice) Prodrug of Glutathione Crankshaw, Daune L. Briggs, Jacquie E. Vince, Robert Nagasawa, Herbert T. Antioxidants (Basel) Communication L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned. MDPI 2021-06-10 /pmc/articles/PMC8226670/ /pubmed/34200599 http://dx.doi.org/10.3390/antiox10060939 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Crankshaw, Daune L.
Briggs, Jacquie E.
Vince, Robert
Nagasawa, Herbert T.
An Orally Bioavailable (Mice) Prodrug of Glutathione
title An Orally Bioavailable (Mice) Prodrug of Glutathione
title_full An Orally Bioavailable (Mice) Prodrug of Glutathione
title_fullStr An Orally Bioavailable (Mice) Prodrug of Glutathione
title_full_unstemmed An Orally Bioavailable (Mice) Prodrug of Glutathione
title_short An Orally Bioavailable (Mice) Prodrug of Glutathione
title_sort orally bioavailable (mice) prodrug of glutathione
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226670/
https://www.ncbi.nlm.nih.gov/pubmed/34200599
http://dx.doi.org/10.3390/antiox10060939
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