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Virus Inactivation in Water Using Laser-Induced Graphene Filters
Interest in the pathogenesis, detection, and prevention of viral infections has increased broadly in many fields of research over the past year. The development of water treatment technology to combat viral infection by inactivation or disinfection might play a key role in infection prevention in pl...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226673/ https://www.ncbi.nlm.nih.gov/pubmed/34207716 http://dx.doi.org/10.3390/ma14123179 |
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author | Barbhuiya, Najmul Haque Singh, Swatantra P. Makovitzki, Arik Narkhede, Pradnya Oren, Ziv Adar, Yaakov Lupu, Edith Cherry, Lilach Monash, Arik Arnusch, Christopher J. |
author_facet | Barbhuiya, Najmul Haque Singh, Swatantra P. Makovitzki, Arik Narkhede, Pradnya Oren, Ziv Adar, Yaakov Lupu, Edith Cherry, Lilach Monash, Arik Arnusch, Christopher J. |
author_sort | Barbhuiya, Najmul Haque |
collection | PubMed |
description | Interest in the pathogenesis, detection, and prevention of viral infections has increased broadly in many fields of research over the past year. The development of water treatment technology to combat viral infection by inactivation or disinfection might play a key role in infection prevention in places where drinking water sources are biologically contaminated. Laser-induced graphene (LIG) has antimicrobial and antifouling surface effects mainly because of its electrochemical properties and texture, and LIG-based water filters have been used for the inactivation of bacteria. However, the antiviral activity of LIG-based filters has not yet been explored. Here we show that LIG filters also have antiviral effects by applying electrical potential during filtration of the model prototypic poxvirus Vaccinia lister. This antiviral activity of the LIG filters was compared with its antibacterial activity, which showed that higher voltages were required for the inactivation of viruses compared to that of bacteria. The generation of reactive oxygen species, along with surface electrical effects, played a role in the mechanism of virus inactivation. This new property of LIG highlights its potential for use in water and wastewater treatment for the electrochemical disinfection of various pathogenic microorganisms, including bacteria and viruses. |
format | Online Article Text |
id | pubmed-8226673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82266732021-06-26 Virus Inactivation in Water Using Laser-Induced Graphene Filters Barbhuiya, Najmul Haque Singh, Swatantra P. Makovitzki, Arik Narkhede, Pradnya Oren, Ziv Adar, Yaakov Lupu, Edith Cherry, Lilach Monash, Arik Arnusch, Christopher J. Materials (Basel) Article Interest in the pathogenesis, detection, and prevention of viral infections has increased broadly in many fields of research over the past year. The development of water treatment technology to combat viral infection by inactivation or disinfection might play a key role in infection prevention in places where drinking water sources are biologically contaminated. Laser-induced graphene (LIG) has antimicrobial and antifouling surface effects mainly because of its electrochemical properties and texture, and LIG-based water filters have been used for the inactivation of bacteria. However, the antiviral activity of LIG-based filters has not yet been explored. Here we show that LIG filters also have antiviral effects by applying electrical potential during filtration of the model prototypic poxvirus Vaccinia lister. This antiviral activity of the LIG filters was compared with its antibacterial activity, which showed that higher voltages were required for the inactivation of viruses compared to that of bacteria. The generation of reactive oxygen species, along with surface electrical effects, played a role in the mechanism of virus inactivation. This new property of LIG highlights its potential for use in water and wastewater treatment for the electrochemical disinfection of various pathogenic microorganisms, including bacteria and viruses. MDPI 2021-06-09 /pmc/articles/PMC8226673/ /pubmed/34207716 http://dx.doi.org/10.3390/ma14123179 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barbhuiya, Najmul Haque Singh, Swatantra P. Makovitzki, Arik Narkhede, Pradnya Oren, Ziv Adar, Yaakov Lupu, Edith Cherry, Lilach Monash, Arik Arnusch, Christopher J. Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title | Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title_full | Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title_fullStr | Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title_full_unstemmed | Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title_short | Virus Inactivation in Water Using Laser-Induced Graphene Filters |
title_sort | virus inactivation in water using laser-induced graphene filters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226673/ https://www.ncbi.nlm.nih.gov/pubmed/34207716 http://dx.doi.org/10.3390/ma14123179 |
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