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DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 202...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226681/ https://www.ncbi.nlm.nih.gov/pubmed/34205940 http://dx.doi.org/10.3390/v13061046 |
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author | Casucci, Gerardo Acanfora, Domenico |
author_facet | Casucci, Gerardo Acanfora, Domenico |
author_sort | Casucci, Gerardo |
collection | PubMed |
description | In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs. |
format | Online Article Text |
id | pubmed-8226681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82266812021-06-26 DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination Casucci, Gerardo Acanfora, Domenico Viruses Case Report In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs. MDPI 2021-06-01 /pmc/articles/PMC8226681/ /pubmed/34205940 http://dx.doi.org/10.3390/v13061046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Casucci, Gerardo Acanfora, Domenico DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title | DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_full | DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_fullStr | DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_full_unstemmed | DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_short | DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination |
title_sort | dic-like syndrome following administration of chadox1 ncov-19 vaccination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226681/ https://www.ncbi.nlm.nih.gov/pubmed/34205940 http://dx.doi.org/10.3390/v13061046 |
work_keys_str_mv | AT casuccigerardo diclikesyndromefollowingadministrationofchadox1ncov19vaccination AT acanforadomenico diclikesyndromefollowingadministrationofchadox1ncov19vaccination |