Cargando…

DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination

In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 202...

Descripción completa

Detalles Bibliográficos
Autores principales: Casucci, Gerardo, Acanfora, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226681/
https://www.ncbi.nlm.nih.gov/pubmed/34205940
http://dx.doi.org/10.3390/v13061046
_version_ 1783712344796299264
author Casucci, Gerardo
Acanfora, Domenico
author_facet Casucci, Gerardo
Acanfora, Domenico
author_sort Casucci, Gerardo
collection PubMed
description In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs.
format Online
Article
Text
id pubmed-8226681
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82266812021-06-26 DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination Casucci, Gerardo Acanfora, Domenico Viruses Case Report In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs. MDPI 2021-06-01 /pmc/articles/PMC8226681/ /pubmed/34205940 http://dx.doi.org/10.3390/v13061046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Casucci, Gerardo
Acanfora, Domenico
DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title_full DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title_fullStr DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title_full_unstemmed DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title_short DIC-Like Syndrome Following Administration of ChAdOx1 nCov-19 Vaccination
title_sort dic-like syndrome following administration of chadox1 ncov-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226681/
https://www.ncbi.nlm.nih.gov/pubmed/34205940
http://dx.doi.org/10.3390/v13061046
work_keys_str_mv AT casuccigerardo diclikesyndromefollowingadministrationofchadox1ncov19vaccination
AT acanforadomenico diclikesyndromefollowingadministrationofchadox1ncov19vaccination