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Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality

Background: anemia is known to be a risk factor for developing ischemic stroke in long-term follow-up studies, and it is also known to increase the risk of death in ischemic stroke patients. We aimed to determine the association of anemia with the risk of ischemic stroke and the risk of death after...

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Autores principales: Heo, Jayoon, Youk, Tae-Mi, Seo, Kwon-Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226740/
https://www.ncbi.nlm.nih.gov/pubmed/34207841
http://dx.doi.org/10.3390/jcm10122556
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author Heo, Jayoon
Youk, Tae-Mi
Seo, Kwon-Duk
author_facet Heo, Jayoon
Youk, Tae-Mi
Seo, Kwon-Duk
author_sort Heo, Jayoon
collection PubMed
description Background: anemia is known to be a risk factor for developing ischemic stroke in long-term follow-up studies, and it is also known to increase the risk of death in ischemic stroke patients. We aimed to determine the association of anemia with the risk of ischemic stroke and the risk of death after ischemic stroke. Methods: The study included patients from National Health Insurance Service cohort, from January 2005 to December 2015. Anemia patients were defined as those with confirmed diagnostic codes and related medications in the sample cohort, and patients under the age of 18 were excluded. To perform a comparative analysis with the control group, twice as many patients were extracted by propensity score matching. The effects of anemia on the development of ischemic stroke were analyzed. Results: A total of 58,699 patients were newly diagnosed with anemia during the study period. In anemia group, the rate of ischemic stroke occurring within 1 year was 0.550%, and the rate was 0.272% in the control group. The odds ratio of anemia related to ischemic stroke was 1.602 (95% confidence intervals (CI) 1.363–1.883). During the follow-up period, 175 out of 309 (56.6%) died in anemia group, and 130 out of 314 (41.4%) died in control group. The anemia group showed a higher risk of death than the control group (Hazard ratio 1.509, 95% CI 1.197–1.902). Conclusion: Analysis of the nationwide health insurance data revealed that anemia is one of the risk factors for the development of ischemic stroke, and also an independent prognostic factor affecting post-stroke mortality.
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spelling pubmed-82267402021-06-26 Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality Heo, Jayoon Youk, Tae-Mi Seo, Kwon-Duk J Clin Med Article Background: anemia is known to be a risk factor for developing ischemic stroke in long-term follow-up studies, and it is also known to increase the risk of death in ischemic stroke patients. We aimed to determine the association of anemia with the risk of ischemic stroke and the risk of death after ischemic stroke. Methods: The study included patients from National Health Insurance Service cohort, from January 2005 to December 2015. Anemia patients were defined as those with confirmed diagnostic codes and related medications in the sample cohort, and patients under the age of 18 were excluded. To perform a comparative analysis with the control group, twice as many patients were extracted by propensity score matching. The effects of anemia on the development of ischemic stroke were analyzed. Results: A total of 58,699 patients were newly diagnosed with anemia during the study period. In anemia group, the rate of ischemic stroke occurring within 1 year was 0.550%, and the rate was 0.272% in the control group. The odds ratio of anemia related to ischemic stroke was 1.602 (95% confidence intervals (CI) 1.363–1.883). During the follow-up period, 175 out of 309 (56.6%) died in anemia group, and 130 out of 314 (41.4%) died in control group. The anemia group showed a higher risk of death than the control group (Hazard ratio 1.509, 95% CI 1.197–1.902). Conclusion: Analysis of the nationwide health insurance data revealed that anemia is one of the risk factors for the development of ischemic stroke, and also an independent prognostic factor affecting post-stroke mortality. MDPI 2021-06-09 /pmc/articles/PMC8226740/ /pubmed/34207841 http://dx.doi.org/10.3390/jcm10122556 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heo, Jayoon
Youk, Tae-Mi
Seo, Kwon-Duk
Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title_full Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title_fullStr Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title_full_unstemmed Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title_short Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality
title_sort anemia is a risk factor for the development of ischemic stroke and post-stroke mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226740/
https://www.ncbi.nlm.nih.gov/pubmed/34207841
http://dx.doi.org/10.3390/jcm10122556
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