Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster

Field epidemiology and viral sequencing provide a comprehensive characterization of transmission chains and allow a better identification of superspreading events. However, very few examples have been presented to date during the COVID-19 pandemic. We studied the first COVID-19 cluster detected in P...

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Detalles Bibliográficos
Autores principales: Pedro, Nicole, Fernandes, Veronica, Cavadas, Bruno, Guimarães, João Tiago, Barros, Henrique, Tavares, Margarida, Pereira, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226748/
https://www.ncbi.nlm.nih.gov/pubmed/34200621
http://dx.doi.org/10.3390/v13061116
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author Pedro, Nicole
Fernandes, Veronica
Cavadas, Bruno
Guimarães, João Tiago
Barros, Henrique
Tavares, Margarida
Pereira, Luisa
author_facet Pedro, Nicole
Fernandes, Veronica
Cavadas, Bruno
Guimarães, João Tiago
Barros, Henrique
Tavares, Margarida
Pereira, Luisa
author_sort Pedro, Nicole
collection PubMed
description Field epidemiology and viral sequencing provide a comprehensive characterization of transmission chains and allow a better identification of superspreading events. However, very few examples have been presented to date during the COVID-19 pandemic. We studied the first COVID-19 cluster detected in Portugal (59 individuals involved amongst extended family and work environments), following the return of four related individuals from work trips to Italy. The first patient to introduce the virus would be misidentified following the traditional field inquiry alone, as shown by the viral sequencing in isolates from 23 individuals. The results also pointed out family, and not work environment, as the primary mode of transmission.
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spelling pubmed-82267482021-06-26 Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster Pedro, Nicole Fernandes, Veronica Cavadas, Bruno Guimarães, João Tiago Barros, Henrique Tavares, Margarida Pereira, Luisa Viruses Brief Report Field epidemiology and viral sequencing provide a comprehensive characterization of transmission chains and allow a better identification of superspreading events. However, very few examples have been presented to date during the COVID-19 pandemic. We studied the first COVID-19 cluster detected in Portugal (59 individuals involved amongst extended family and work environments), following the return of four related individuals from work trips to Italy. The first patient to introduce the virus would be misidentified following the traditional field inquiry alone, as shown by the viral sequencing in isolates from 23 individuals. The results also pointed out family, and not work environment, as the primary mode of transmission. MDPI 2021-06-10 /pmc/articles/PMC8226748/ /pubmed/34200621 http://dx.doi.org/10.3390/v13061116 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Pedro, Nicole
Fernandes, Veronica
Cavadas, Bruno
Guimarães, João Tiago
Barros, Henrique
Tavares, Margarida
Pereira, Luisa
Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title_full Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title_fullStr Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title_full_unstemmed Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title_short Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster
title_sort field and molecular epidemiology: how viral sequencing changed transmission inferences in the first portuguese sars-cov-2 infection cluster
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226748/
https://www.ncbi.nlm.nih.gov/pubmed/34200621
http://dx.doi.org/10.3390/v13061116
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