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Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2

SIMPLE SUMMARY: With the COVID-19 pandemic lasting over a year and affecting all continents, a new problem has arisen—that of convalescents, who continue to have various symptoms at more than 4 and up to 12 weeks after the acute disease, the so called post-acute COVID-19 syndrome. In this article, w...

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Autores principales: Tudoran, Cristina, Tudoran, Mariana, Pop, Gheorghe Nicusor, Giurgi-Oncu, Catalina, Cut, Talida Georgiana, Lazureanu, Voichita Elena, Oancea, Cristian, Parv, Florina, Ciocarlie, Tudor, Bende, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226755/
https://www.ncbi.nlm.nih.gov/pubmed/34073342
http://dx.doi.org/10.3390/biology10060469
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author Tudoran, Cristina
Tudoran, Mariana
Pop, Gheorghe Nicusor
Giurgi-Oncu, Catalina
Cut, Talida Georgiana
Lazureanu, Voichita Elena
Oancea, Cristian
Parv, Florina
Ciocarlie, Tudor
Bende, Felix
author_facet Tudoran, Cristina
Tudoran, Mariana
Pop, Gheorghe Nicusor
Giurgi-Oncu, Catalina
Cut, Talida Georgiana
Lazureanu, Voichita Elena
Oancea, Cristian
Parv, Florina
Ciocarlie, Tudor
Bende, Felix
author_sort Tudoran, Cristina
collection PubMed
description SIMPLE SUMMARY: With the COVID-19 pandemic lasting over a year and affecting all continents, a new problem has arisen—that of convalescents, who continue to have various symptoms at more than 4 and up to 12 weeks after the acute disease, the so called post-acute COVID-19 syndrome. In this article, we tried to determine if previously healthy adults with post-acute COVID-19 syndrome also have cardiac complications related to the number of persisting symptoms, the quality of life scores and the initial pulmonary injury. Using transthoracic echocardiography, we found cardiac abnormalities (pulmonary hypertension, systolic and diastolic dysfunction, pericarditis) in about a quarter of the 150 participants in our study. Their gravity was significantly correlated with the severity of COVID-19, the number of weeks passed since the acute illness, the number of persisting symptoms, and the quality of life. Post-acute COVID-19 is a recently proposed term which aims to characterize the various symptoms persisting after an acute SARS-CoV-2 infection, their severity being explained partially by residual multi-system alterations, with an important impact on the functional status and quality of life of the affected individuals. ABSTRACT: The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without a history of cardiovascular diseases, treated as outpatients for a mild/moderate form of COVID-19 4 to 12 weeks prior to study inclusion, and who were diagnosed with post-acute COVID-19 and attended a cardiology evaluation with transthoracic echocardiography (TTE) for persisting symptoms. We detected various cardiac abnormalities in 38 subjects (25.33%), including pulmonary hypertension (9.33%), impaired left ventricular performance (8.66%), diastolic dysfunction (14%) and/or evidence of pericarditis (10%). We highlighted statistically significant correlations between the intensity of symptoms and quality of life scores with the severity of initial pulmonary injury, the number of weeks since COVID-19 and with TTE parameters characterizing the systolic and diastolic performance and pulmonary hypertension (p < 0.001). (Post-acute COVID-19 is a complex syndrome characterized by various symptoms, the intensity of which seem to be related to the severity and the time elapsed since the acute infection, and with persisting cardiac abnormalities.
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spelling pubmed-82267552021-06-26 Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 Tudoran, Cristina Tudoran, Mariana Pop, Gheorghe Nicusor Giurgi-Oncu, Catalina Cut, Talida Georgiana Lazureanu, Voichita Elena Oancea, Cristian Parv, Florina Ciocarlie, Tudor Bende, Felix Biology (Basel) Article SIMPLE SUMMARY: With the COVID-19 pandemic lasting over a year and affecting all continents, a new problem has arisen—that of convalescents, who continue to have various symptoms at more than 4 and up to 12 weeks after the acute disease, the so called post-acute COVID-19 syndrome. In this article, we tried to determine if previously healthy adults with post-acute COVID-19 syndrome also have cardiac complications related to the number of persisting symptoms, the quality of life scores and the initial pulmonary injury. Using transthoracic echocardiography, we found cardiac abnormalities (pulmonary hypertension, systolic and diastolic dysfunction, pericarditis) in about a quarter of the 150 participants in our study. Their gravity was significantly correlated with the severity of COVID-19, the number of weeks passed since the acute illness, the number of persisting symptoms, and the quality of life. Post-acute COVID-19 is a recently proposed term which aims to characterize the various symptoms persisting after an acute SARS-CoV-2 infection, their severity being explained partially by residual multi-system alterations, with an important impact on the functional status and quality of life of the affected individuals. ABSTRACT: The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without a history of cardiovascular diseases, treated as outpatients for a mild/moderate form of COVID-19 4 to 12 weeks prior to study inclusion, and who were diagnosed with post-acute COVID-19 and attended a cardiology evaluation with transthoracic echocardiography (TTE) for persisting symptoms. We detected various cardiac abnormalities in 38 subjects (25.33%), including pulmonary hypertension (9.33%), impaired left ventricular performance (8.66%), diastolic dysfunction (14%) and/or evidence of pericarditis (10%). We highlighted statistically significant correlations between the intensity of symptoms and quality of life scores with the severity of initial pulmonary injury, the number of weeks since COVID-19 and with TTE parameters characterizing the systolic and diastolic performance and pulmonary hypertension (p < 0.001). (Post-acute COVID-19 is a complex syndrome characterized by various symptoms, the intensity of which seem to be related to the severity and the time elapsed since the acute infection, and with persisting cardiac abnormalities. MDPI 2021-05-26 /pmc/articles/PMC8226755/ /pubmed/34073342 http://dx.doi.org/10.3390/biology10060469 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tudoran, Cristina
Tudoran, Mariana
Pop, Gheorghe Nicusor
Giurgi-Oncu, Catalina
Cut, Talida Georgiana
Lazureanu, Voichita Elena
Oancea, Cristian
Parv, Florina
Ciocarlie, Tudor
Bende, Felix
Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title_full Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title_fullStr Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title_full_unstemmed Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title_short Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
title_sort associations between the severity of the post-acute covid-19 syndrome and echocardiographic abnormalities in previously healthy outpatients following infection with sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226755/
https://www.ncbi.nlm.nih.gov/pubmed/34073342
http://dx.doi.org/10.3390/biology10060469
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