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Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population
Background: Antibody dynamics over time after SARS-CoV-2 infection are still unclear, and data regarding children are scarce. Methods: A prospective cohort study was performed including children infected by SARS-CoV-2 between March and May 2020. Patients were categorized into 3 groups: children admi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226775/ https://www.ncbi.nlm.nih.gov/pubmed/34199852 http://dx.doi.org/10.3390/pathogens10060700 |
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author | Méndez-Echevarría, Ana Sainz, Talía Falces-Romero, Iker de Felipe, Beatriz Escolano, Lucia Alcolea, Sonia Pertiñez, Lidia Neth, Olaf Calvo, Cristina |
author_facet | Méndez-Echevarría, Ana Sainz, Talía Falces-Romero, Iker de Felipe, Beatriz Escolano, Lucia Alcolea, Sonia Pertiñez, Lidia Neth, Olaf Calvo, Cristina |
author_sort | Méndez-Echevarría, Ana |
collection | PubMed |
description | Background: Antibody dynamics over time after SARS-CoV-2 infection are still unclear, and data regarding children are scarce. Methods: A prospective cohort study was performed including children infected by SARS-CoV-2 between March and May 2020. Patients were categorized into 3 groups: children admitted with COVID-19; outpatient children with mild COVID-19; and seropositive children participating in a seroprevalence study among cohabitants of infected healthcare workers (HCWs). Six months after the infection, a new serological control was performed. Results: A total of 58 children were included, 50% male (median age 8.3 [IQR 2.8–13.5] years). The median time between the two serological studies was 186 (IQR 176–192) days, and 86% (48/56) of the children maintained positive IgG six months after the infection. This percentage was 100% in admitted patients and 78% among the rest of the included children (p = 0.022). The diagnoses of lower respiratory tract infection and multisystemic inflammatory syndrome were associated with persistence of IgG (p = 0.035). The children of HCWs in the seroprevalence study lost antibodies more often (p = 0.017). Initial IgG titers of the children who remained positive six months after the infection were significantly higher (p = 0.008). Conclusions: Most children infected by SARS-CoV-2 maintain a positive serological response six months after the infection. Those children who lost their IgG titer were more frequently asymptomatic or mildly symptomatic, presenting with low antibody titers after the infection. |
format | Online Article Text |
id | pubmed-8226775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82267752021-06-26 Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population Méndez-Echevarría, Ana Sainz, Talía Falces-Romero, Iker de Felipe, Beatriz Escolano, Lucia Alcolea, Sonia Pertiñez, Lidia Neth, Olaf Calvo, Cristina Pathogens Article Background: Antibody dynamics over time after SARS-CoV-2 infection are still unclear, and data regarding children are scarce. Methods: A prospective cohort study was performed including children infected by SARS-CoV-2 between March and May 2020. Patients were categorized into 3 groups: children admitted with COVID-19; outpatient children with mild COVID-19; and seropositive children participating in a seroprevalence study among cohabitants of infected healthcare workers (HCWs). Six months after the infection, a new serological control was performed. Results: A total of 58 children were included, 50% male (median age 8.3 [IQR 2.8–13.5] years). The median time between the two serological studies was 186 (IQR 176–192) days, and 86% (48/56) of the children maintained positive IgG six months after the infection. This percentage was 100% in admitted patients and 78% among the rest of the included children (p = 0.022). The diagnoses of lower respiratory tract infection and multisystemic inflammatory syndrome were associated with persistence of IgG (p = 0.035). The children of HCWs in the seroprevalence study lost antibodies more often (p = 0.017). Initial IgG titers of the children who remained positive six months after the infection were significantly higher (p = 0.008). Conclusions: Most children infected by SARS-CoV-2 maintain a positive serological response six months after the infection. Those children who lost their IgG titer were more frequently asymptomatic or mildly symptomatic, presenting with low antibody titers after the infection. MDPI 2021-06-04 /pmc/articles/PMC8226775/ /pubmed/34199852 http://dx.doi.org/10.3390/pathogens10060700 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Méndez-Echevarría, Ana Sainz, Talía Falces-Romero, Iker de Felipe, Beatriz Escolano, Lucia Alcolea, Sonia Pertiñez, Lidia Neth, Olaf Calvo, Cristina Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title | Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title_full | Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title_fullStr | Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title_full_unstemmed | Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title_short | Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population |
title_sort | long-term persistence of anti-sars-cov-2 antibodies in a pediatric population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226775/ https://www.ncbi.nlm.nih.gov/pubmed/34199852 http://dx.doi.org/10.3390/pathogens10060700 |
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