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Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226870/ https://www.ncbi.nlm.nih.gov/pubmed/34200194 http://dx.doi.org/10.3390/children8060482 |
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author | Paraboschi, Irene Privitera, Laura Kramer-Marek, Gabriela Anderson, John Giuliani, Stefano |
author_facet | Paraboschi, Irene Privitera, Laura Kramer-Marek, Gabriela Anderson, John Giuliani, Stefano |
author_sort | Paraboschi, Irene |
collection | PubMed |
description | Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment. |
format | Online Article Text |
id | pubmed-8226870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82268702021-06-26 Novel Treatments and Technologies Applied to the Cure of Neuroblastoma Paraboschi, Irene Privitera, Laura Kramer-Marek, Gabriela Anderson, John Giuliani, Stefano Children (Basel) Review Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment. MDPI 2021-06-07 /pmc/articles/PMC8226870/ /pubmed/34200194 http://dx.doi.org/10.3390/children8060482 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Paraboschi, Irene Privitera, Laura Kramer-Marek, Gabriela Anderson, John Giuliani, Stefano Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title | Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title_full | Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title_fullStr | Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title_full_unstemmed | Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title_short | Novel Treatments and Technologies Applied to the Cure of Neuroblastoma |
title_sort | novel treatments and technologies applied to the cure of neuroblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226870/ https://www.ncbi.nlm.nih.gov/pubmed/34200194 http://dx.doi.org/10.3390/children8060482 |
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