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Novel Treatments and Technologies Applied to the Cure of Neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival...

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Autores principales: Paraboschi, Irene, Privitera, Laura, Kramer-Marek, Gabriela, Anderson, John, Giuliani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226870/
https://www.ncbi.nlm.nih.gov/pubmed/34200194
http://dx.doi.org/10.3390/children8060482
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author Paraboschi, Irene
Privitera, Laura
Kramer-Marek, Gabriela
Anderson, John
Giuliani, Stefano
author_facet Paraboschi, Irene
Privitera, Laura
Kramer-Marek, Gabriela
Anderson, John
Giuliani, Stefano
author_sort Paraboschi, Irene
collection PubMed
description Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment.
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spelling pubmed-82268702021-06-26 Novel Treatments and Technologies Applied to the Cure of Neuroblastoma Paraboschi, Irene Privitera, Laura Kramer-Marek, Gabriela Anderson, John Giuliani, Stefano Children (Basel) Review Neuroblastoma (NB) is the most common extracranial solid tumour in childhood, accounting for approximately 15% of all cancer-related deaths in the paediatric population1. It is characterised by heterogeneous clinical behaviour in neonates and often adverse outcomes in toddlers. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols consisting of intensive chemotherapy, surgery, radiation therapy and hematopoietic stem cell transplantation2,3. There is an ongoing research effort to increase NB’s cellular and molecular biology knowledge to translate essential findings into novel treatment strategies. This review aims to address new therapeutic modalities emerging from preclinical studies offering a unique translational opportunity for NB treatment. MDPI 2021-06-07 /pmc/articles/PMC8226870/ /pubmed/34200194 http://dx.doi.org/10.3390/children8060482 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paraboschi, Irene
Privitera, Laura
Kramer-Marek, Gabriela
Anderson, John
Giuliani, Stefano
Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title_full Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title_fullStr Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title_full_unstemmed Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title_short Novel Treatments and Technologies Applied to the Cure of Neuroblastoma
title_sort novel treatments and technologies applied to the cure of neuroblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226870/
https://www.ncbi.nlm.nih.gov/pubmed/34200194
http://dx.doi.org/10.3390/children8060482
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