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New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature

Background and Objectives: Over the past twenty years a large number of new psychoactive substances (NPS) have entered and modified the recreational drug scene. Their intake has been associated with health-related risks, especially so for vulnerable populations such as people with severe mental illn...

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Autores principales: Chiappini, Stefania, Mosca, Alessio, Miuli, Andrea, Santovito, Maria Chiara, Orsolini, Laura, Corkery, John Martin, Guirguis, Amira, Pettorruso, Mauro, Martinotti, Giovanni, Di Giannantonio, Massimo, Schifano, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226910/
https://www.ncbi.nlm.nih.gov/pubmed/34204131
http://dx.doi.org/10.3390/medicina57060580
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author Chiappini, Stefania
Mosca, Alessio
Miuli, Andrea
Santovito, Maria Chiara
Orsolini, Laura
Corkery, John Martin
Guirguis, Amira
Pettorruso, Mauro
Martinotti, Giovanni
Di Giannantonio, Massimo
Schifano, Fabrizio
author_facet Chiappini, Stefania
Mosca, Alessio
Miuli, Andrea
Santovito, Maria Chiara
Orsolini, Laura
Corkery, John Martin
Guirguis, Amira
Pettorruso, Mauro
Martinotti, Giovanni
Di Giannantonio, Massimo
Schifano, Fabrizio
author_sort Chiappini, Stefania
collection PubMed
description Background and Objectives: Over the past twenty years a large number of new psychoactive substances (NPS) have entered and modified the recreational drug scene. Their intake has been associated with health-related risks, especially so for vulnerable populations such as people with severe mental illness, who might be at higher risk of suicidality or self-injurious behavior. This paper aims at providing an overview of NPS abuse and the effects on mental health and suicidality issues, by performing a literature review of the current related knowledge, thereby identifying those substances that, more than others, are linked to suicidal behaviors. Materials and Methods: A comprehensive and updated overview of the literature regarding suicidality and NPS categories has been undertaken. An electronic search was performed, including all papers published up to March 2021, using the following keywords “NPS” OR “new psychoactive substances” OR “novel psychoactive substances” OR “synthetic cannabinoids” OR “phenethylamines” OR “synthetic cathinones” OR “tryptamines” OR “piperazines” OR “new synthetic opioids” OR “designer benzodiazepines” AND (“suicide” OR “suicidality”) NOT review NOT animal on the PubMed, Cochrane Library, and Web of Science online databases. Results: Suicidality and self-injurious behavior appear to be frequently associated with some NPS such as cathinones, synthetic cannabinoids, and new synthetic opioids. The results are organized according to the substances recorded. Conclusion: The growing use of NPS has become a significant clinical issue, causing increasing concern and challenges for clinicians working in both mental health and emergency departments. Thus, considering the associations between NPS and suicidality or self-injurious behaviors, areas where suicide-prevention efforts and strategies might be focused are the early detection, monitoring, and restriction of NPS.
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spelling pubmed-82269102021-06-26 New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature Chiappini, Stefania Mosca, Alessio Miuli, Andrea Santovito, Maria Chiara Orsolini, Laura Corkery, John Martin Guirguis, Amira Pettorruso, Mauro Martinotti, Giovanni Di Giannantonio, Massimo Schifano, Fabrizio Medicina (Kaunas) Review Background and Objectives: Over the past twenty years a large number of new psychoactive substances (NPS) have entered and modified the recreational drug scene. Their intake has been associated with health-related risks, especially so for vulnerable populations such as people with severe mental illness, who might be at higher risk of suicidality or self-injurious behavior. This paper aims at providing an overview of NPS abuse and the effects on mental health and suicidality issues, by performing a literature review of the current related knowledge, thereby identifying those substances that, more than others, are linked to suicidal behaviors. Materials and Methods: A comprehensive and updated overview of the literature regarding suicidality and NPS categories has been undertaken. An electronic search was performed, including all papers published up to March 2021, using the following keywords “NPS” OR “new psychoactive substances” OR “novel psychoactive substances” OR “synthetic cannabinoids” OR “phenethylamines” OR “synthetic cathinones” OR “tryptamines” OR “piperazines” OR “new synthetic opioids” OR “designer benzodiazepines” AND (“suicide” OR “suicidality”) NOT review NOT animal on the PubMed, Cochrane Library, and Web of Science online databases. Results: Suicidality and self-injurious behavior appear to be frequently associated with some NPS such as cathinones, synthetic cannabinoids, and new synthetic opioids. The results are organized according to the substances recorded. Conclusion: The growing use of NPS has become a significant clinical issue, causing increasing concern and challenges for clinicians working in both mental health and emergency departments. Thus, considering the associations between NPS and suicidality or self-injurious behaviors, areas where suicide-prevention efforts and strategies might be focused are the early detection, monitoring, and restriction of NPS. MDPI 2021-06-06 /pmc/articles/PMC8226910/ /pubmed/34204131 http://dx.doi.org/10.3390/medicina57060580 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chiappini, Stefania
Mosca, Alessio
Miuli, Andrea
Santovito, Maria Chiara
Orsolini, Laura
Corkery, John Martin
Guirguis, Amira
Pettorruso, Mauro
Martinotti, Giovanni
Di Giannantonio, Massimo
Schifano, Fabrizio
New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title_full New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title_fullStr New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title_full_unstemmed New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title_short New Psychoactive Substances and Suicidality: A Systematic Review of the Current Literature
title_sort new psychoactive substances and suicidality: a systematic review of the current literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226910/
https://www.ncbi.nlm.nih.gov/pubmed/34204131
http://dx.doi.org/10.3390/medicina57060580
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