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Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study

Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choic...

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Detalles Bibliográficos
Autores principales: Murawiec, Sławomir, Krzystanek, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226947/
https://www.ncbi.nlm.nih.gov/pubmed/34072934
http://dx.doi.org/10.3390/ph14060526
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author Murawiec, Sławomir
Krzystanek, Marek
author_facet Murawiec, Sławomir
Krzystanek, Marek
author_sort Murawiec, Sławomir
collection PubMed
description Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choice of antidepressants may be based on matching their mechanisms of action to the symptomatic profiles of depression, reflecting the heterogeneity of symptoms in different patients. The authors presented a series of cases of patients diagnosed with depression in whom at least one previous antidepressant treatment was shown to be ineffective before drug targeted symptom cluster-matching treatment (SCMT). The presented pilot study shows for the first time the effectiveness of SCMT in the different clusters of depressive symptoms. All the described patients obtained recovery from depressive symptoms after introducing drug-targeted SCMT. Once validated in clinical trials, SCMT might become an effective and rational method of selecting an antidepressant according to the individual profile of depressive symptoms, the mechanism of their formation, and the mechanism of drug action. Although the study results are preliminary, SCMT can be a way to personalize treatment, increasing the likelihood of improvement even in patients who meet criteria for treatment-resistant depression.
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spelling pubmed-82269472021-06-26 Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study Murawiec, Sławomir Krzystanek, Marek Pharmaceuticals (Basel) Communication Despite treating depression with antidepressants, their effectiveness is often insufficient. Comparative effectiveness studies and meta-analyses show the effectiveness of antidepressants; however, they do not provide clear indications as to the choice of a specific antidepressant. The rational choice of antidepressants may be based on matching their mechanisms of action to the symptomatic profiles of depression, reflecting the heterogeneity of symptoms in different patients. The authors presented a series of cases of patients diagnosed with depression in whom at least one previous antidepressant treatment was shown to be ineffective before drug targeted symptom cluster-matching treatment (SCMT). The presented pilot study shows for the first time the effectiveness of SCMT in the different clusters of depressive symptoms. All the described patients obtained recovery from depressive symptoms after introducing drug-targeted SCMT. Once validated in clinical trials, SCMT might become an effective and rational method of selecting an antidepressant according to the individual profile of depressive symptoms, the mechanism of their formation, and the mechanism of drug action. Although the study results are preliminary, SCMT can be a way to personalize treatment, increasing the likelihood of improvement even in patients who meet criteria for treatment-resistant depression. MDPI 2021-05-31 /pmc/articles/PMC8226947/ /pubmed/34072934 http://dx.doi.org/10.3390/ph14060526 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Murawiec, Sławomir
Krzystanek, Marek
Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title_full Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title_fullStr Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title_full_unstemmed Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title_short Symptom Cluster-Matching Antidepressant Treatment: A Case Series Pilot Study
title_sort symptom cluster-matching antidepressant treatment: a case series pilot study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226947/
https://www.ncbi.nlm.nih.gov/pubmed/34072934
http://dx.doi.org/10.3390/ph14060526
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