Subcellular Localization of miRNAs and Implications in Cellular Homeostasis

MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization...

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Autores principales: Jie, Minwen, Feng, Tong, Huang, Wei, Zhang, Moran, Feng, Yuliang, Jiang, Hao, Wen, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226975/
https://www.ncbi.nlm.nih.gov/pubmed/34199614
http://dx.doi.org/10.3390/genes12060856
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author Jie, Minwen
Feng, Tong
Huang, Wei
Zhang, Moran
Feng, Yuliang
Jiang, Hao
Wen, Zhili
author_facet Jie, Minwen
Feng, Tong
Huang, Wei
Zhang, Moran
Feng, Yuliang
Jiang, Hao
Wen, Zhili
author_sort Jie, Minwen
collection PubMed
description MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates.
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spelling pubmed-82269752021-06-26 Subcellular Localization of miRNAs and Implications in Cellular Homeostasis Jie, Minwen Feng, Tong Huang, Wei Zhang, Moran Feng, Yuliang Jiang, Hao Wen, Zhili Genes (Basel) Review MicroRNAs (miRNAs) are thought to act as post-transcriptional regulators in the cytoplasm by either dampening translation or stimulating degradation of target mRNAs. With the increasing resolution and scope of RNA mapping, recent studies have revealed novel insights into the subcellular localization of miRNAs. Based on miRNA subcellular localization, unconventional functions and mechanisms at the transcriptional and post-transcriptional levels have been identified. This minireview provides an overview of the subcellular localization of miRNAs and the mechanisms by which they regulate transcription and cellular homeostasis in mammals, with a particular focus on the roles of phase-separated biomolecular condensates. MDPI 2021-06-02 /pmc/articles/PMC8226975/ /pubmed/34199614 http://dx.doi.org/10.3390/genes12060856 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jie, Minwen
Feng, Tong
Huang, Wei
Zhang, Moran
Feng, Yuliang
Jiang, Hao
Wen, Zhili
Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title_full Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title_fullStr Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title_full_unstemmed Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title_short Subcellular Localization of miRNAs and Implications in Cellular Homeostasis
title_sort subcellular localization of mirnas and implications in cellular homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226975/
https://www.ncbi.nlm.nih.gov/pubmed/34199614
http://dx.doi.org/10.3390/genes12060856
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