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Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity

Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical record...

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Autores principales: Carroccio, Antonio, Soresi, Maurizio, Chiavetta, Marta, La Blasca, Francesco, Compagnoni, Stella, Giuliano, Alessandra, Fayer, Francesca, Mandreucci, Francesca, Castellucci, Daniele, Seidita, Aurelio, Affronti, Andrea, Florena, Ada Maria, Mansueto, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227001/
https://www.ncbi.nlm.nih.gov/pubmed/34201313
http://dx.doi.org/10.3390/nu13061971
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author Carroccio, Antonio
Soresi, Maurizio
Chiavetta, Marta
La Blasca, Francesco
Compagnoni, Stella
Giuliano, Alessandra
Fayer, Francesca
Mandreucci, Francesca
Castellucci, Daniele
Seidita, Aurelio
Affronti, Andrea
Florena, Ada Maria
Mansueto, Pasquale
author_facet Carroccio, Antonio
Soresi, Maurizio
Chiavetta, Marta
La Blasca, Francesco
Compagnoni, Stella
Giuliano, Alessandra
Fayer, Francesca
Mandreucci, Francesca
Castellucci, Daniele
Seidita, Aurelio
Affronti, Andrea
Florena, Ada Maria
Mansueto, Pasquale
author_sort Carroccio, Antonio
collection PubMed
description Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical records of NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge between 2006 and 2020, were retrospectively revised. Fifty-two patients with Celiac Disease (CD) and 54 patients with Irritable Bowel Syndrome (IBS) served as controls. Results: 87% of the NCWS patients had an IBS-like clinical presentation. The NCWS group showed a longer duration of symptoms, a higher frequency of positive serum anti-nuclear antibodies than CD and IBS patients, and a higher frequency of DQ2/DQ8 haplotypes and duodenal mucosa lymphocytosis than IBS controls. In addition, 50% of NCWS patients showed neuropsychiatric manifestations, while lower percentages were observed in CD (25%) and IBS (28%) controls. Neuropsychiatric symptoms in NCWS were more frequently associated with the male sex, longer duration of symptoms, and IBS-diarrhea-like clinical presentation. Conclusions: Our data suggest that in patients with IBS-like symptoms and neuropsychiatric manifestations of unknown cause, it could be useful to investigate a correlation of these symptoms with wheat ingestion to identify NCWS patients with this ‘atypical’ manifestation.
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spelling pubmed-82270012021-06-26 Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity Carroccio, Antonio Soresi, Maurizio Chiavetta, Marta La Blasca, Francesco Compagnoni, Stella Giuliano, Alessandra Fayer, Francesca Mandreucci, Francesca Castellucci, Daniele Seidita, Aurelio Affronti, Andrea Florena, Ada Maria Mansueto, Pasquale Nutrients Article Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical records of NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge between 2006 and 2020, were retrospectively revised. Fifty-two patients with Celiac Disease (CD) and 54 patients with Irritable Bowel Syndrome (IBS) served as controls. Results: 87% of the NCWS patients had an IBS-like clinical presentation. The NCWS group showed a longer duration of symptoms, a higher frequency of positive serum anti-nuclear antibodies than CD and IBS patients, and a higher frequency of DQ2/DQ8 haplotypes and duodenal mucosa lymphocytosis than IBS controls. In addition, 50% of NCWS patients showed neuropsychiatric manifestations, while lower percentages were observed in CD (25%) and IBS (28%) controls. Neuropsychiatric symptoms in NCWS were more frequently associated with the male sex, longer duration of symptoms, and IBS-diarrhea-like clinical presentation. Conclusions: Our data suggest that in patients with IBS-like symptoms and neuropsychiatric manifestations of unknown cause, it could be useful to investigate a correlation of these symptoms with wheat ingestion to identify NCWS patients with this ‘atypical’ manifestation. MDPI 2021-06-08 /pmc/articles/PMC8227001/ /pubmed/34201313 http://dx.doi.org/10.3390/nu13061971 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carroccio, Antonio
Soresi, Maurizio
Chiavetta, Marta
La Blasca, Francesco
Compagnoni, Stella
Giuliano, Alessandra
Fayer, Francesca
Mandreucci, Francesca
Castellucci, Daniele
Seidita, Aurelio
Affronti, Andrea
Florena, Ada Maria
Mansueto, Pasquale
Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title_full Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title_fullStr Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title_full_unstemmed Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title_short Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
title_sort frequency and clinical aspects of neurological and psychiatric symptoms in patients with non-celiac wheat sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227001/
https://www.ncbi.nlm.nih.gov/pubmed/34201313
http://dx.doi.org/10.3390/nu13061971
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