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Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity
Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical record...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227001/ https://www.ncbi.nlm.nih.gov/pubmed/34201313 http://dx.doi.org/10.3390/nu13061971 |
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author | Carroccio, Antonio Soresi, Maurizio Chiavetta, Marta La Blasca, Francesco Compagnoni, Stella Giuliano, Alessandra Fayer, Francesca Mandreucci, Francesca Castellucci, Daniele Seidita, Aurelio Affronti, Andrea Florena, Ada Maria Mansueto, Pasquale |
author_facet | Carroccio, Antonio Soresi, Maurizio Chiavetta, Marta La Blasca, Francesco Compagnoni, Stella Giuliano, Alessandra Fayer, Francesca Mandreucci, Francesca Castellucci, Daniele Seidita, Aurelio Affronti, Andrea Florena, Ada Maria Mansueto, Pasquale |
author_sort | Carroccio, Antonio |
collection | PubMed |
description | Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical records of NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge between 2006 and 2020, were retrospectively revised. Fifty-two patients with Celiac Disease (CD) and 54 patients with Irritable Bowel Syndrome (IBS) served as controls. Results: 87% of the NCWS patients had an IBS-like clinical presentation. The NCWS group showed a longer duration of symptoms, a higher frequency of positive serum anti-nuclear antibodies than CD and IBS patients, and a higher frequency of DQ2/DQ8 haplotypes and duodenal mucosa lymphocytosis than IBS controls. In addition, 50% of NCWS patients showed neuropsychiatric manifestations, while lower percentages were observed in CD (25%) and IBS (28%) controls. Neuropsychiatric symptoms in NCWS were more frequently associated with the male sex, longer duration of symptoms, and IBS-diarrhea-like clinical presentation. Conclusions: Our data suggest that in patients with IBS-like symptoms and neuropsychiatric manifestations of unknown cause, it could be useful to investigate a correlation of these symptoms with wheat ingestion to identify NCWS patients with this ‘atypical’ manifestation. |
format | Online Article Text |
id | pubmed-8227001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82270012021-06-26 Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity Carroccio, Antonio Soresi, Maurizio Chiavetta, Marta La Blasca, Francesco Compagnoni, Stella Giuliano, Alessandra Fayer, Francesca Mandreucci, Francesca Castellucci, Daniele Seidita, Aurelio Affronti, Andrea Florena, Ada Maria Mansueto, Pasquale Nutrients Article Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical records of NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge between 2006 and 2020, were retrospectively revised. Fifty-two patients with Celiac Disease (CD) and 54 patients with Irritable Bowel Syndrome (IBS) served as controls. Results: 87% of the NCWS patients had an IBS-like clinical presentation. The NCWS group showed a longer duration of symptoms, a higher frequency of positive serum anti-nuclear antibodies than CD and IBS patients, and a higher frequency of DQ2/DQ8 haplotypes and duodenal mucosa lymphocytosis than IBS controls. In addition, 50% of NCWS patients showed neuropsychiatric manifestations, while lower percentages were observed in CD (25%) and IBS (28%) controls. Neuropsychiatric symptoms in NCWS were more frequently associated with the male sex, longer duration of symptoms, and IBS-diarrhea-like clinical presentation. Conclusions: Our data suggest that in patients with IBS-like symptoms and neuropsychiatric manifestations of unknown cause, it could be useful to investigate a correlation of these symptoms with wheat ingestion to identify NCWS patients with this ‘atypical’ manifestation. MDPI 2021-06-08 /pmc/articles/PMC8227001/ /pubmed/34201313 http://dx.doi.org/10.3390/nu13061971 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carroccio, Antonio Soresi, Maurizio Chiavetta, Marta La Blasca, Francesco Compagnoni, Stella Giuliano, Alessandra Fayer, Francesca Mandreucci, Francesca Castellucci, Daniele Seidita, Aurelio Affronti, Andrea Florena, Ada Maria Mansueto, Pasquale Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title | Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title_full | Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title_fullStr | Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title_full_unstemmed | Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title_short | Frequency and Clinical Aspects of Neurological and Psychiatric Symptoms in Patients with Non-Celiac Wheat Sensitivity |
title_sort | frequency and clinical aspects of neurological and psychiatric symptoms in patients with non-celiac wheat sensitivity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227001/ https://www.ncbi.nlm.nih.gov/pubmed/34201313 http://dx.doi.org/10.3390/nu13061971 |
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