The Kidney-Associated Microbiome of Wild-Caught Artibeus spp. in Grenada, West Indies

SIMPLE SUMMARY: Bats are increasingly being recognized as important integrants of zoonotic disease cycles. Studying bat microbiomes could potentially contribute to the epidemiology of emerging infectious diseases in humans. Furthermore, studying the bat’s microbiome gives us the opportunity to look at the microbiome evolution in mammals. Bat microbiome studies have focused mainly on the gut microbiome, but little is known of the microbiome of the kidney, another potential source of disease transmission. Furthermore, many studies on microbiome found in the literature are based on captive animals, which usually alters the natural microbiome. Here, we analyzed kidney samples of wild-caught Artibeus spp., a fructivorous bat species from Grenada, West Indies, using metagenomics. ABSTRACT: Bats are capable of asymptomatically carrying a diverse number of microorganisms, including human pathogens, due to their unique immune system. Because of the close contact between bats and humans, there is a possibility for interspecies transmission and consequential disease outbreaks. Herein, high-throughput sequencing was used to determine the kidney-associated microbiome of a bat species abundant in Grenada, West Indies, Artibeus spp. Results indicate that the kidney of these bats can carry potential human pathogens. An endogenous retrovirus, Desmodus rotundus endogenous retrovirus isolate 824, phylogenetically related to betaretroviruses from rodents and New World primates, was also identified.