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T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes

Genetic analyses of human type 1 diabetes (T1D) have yet to reveal a complete pathophysiologic mechanism. Inbred rats with a high-risk class II major histocompatibility complex (MHC) haplotype (RT1B/D(u)) can illuminate such mechanisms. Using T1D-susceptible LEW.1WR1 rats that express RT1B/D(u) and...

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Detalles Bibliográficos
Autores principales:	Mordes, John P., Cort, Laura, Liu, Zhijun, Eberwine, Ryan, Blankenhorn, Elizabeth P., Pierce, Brian G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227067/ https://www.ncbi.nlm.nih.gov/pubmed/34205929 http://dx.doi.org/10.3390/genes12060852

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