HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells

SIMPLE SUMMARY: Solid cancers can effectively counteract immune attack by inhibitory checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could be a useful tool for enhancing the efficacy of antitumor T cell therapies. Here, we studied the capacity of two nonclassical H...

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Detalles Bibliográficos
Autores principales: Altvater, Bianca, Kailayangiri, Sareetha, Pérez Lanuza, Lina F., Urban, Katja, Greune, Lea, Flügge, Maike, Meltzer, Jutta, Farwick, Nicole, König, Simone, Görlich, Dennis, Hartmann, Wolfgang, Rossig, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227123/
https://www.ncbi.nlm.nih.gov/pubmed/34201079
http://dx.doi.org/10.3390/cancers13122857

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