3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as...

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Detalles Bibliográficos
Autores principales: Pan, Xinhui, Xin, Xiaobing, Mao, Ying, Li, Xin, Zhao, Yanan, Liu, Yidi, Zhang, Ke, Yang, Xiaoda, Wang, Jinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227129/
https://www.ncbi.nlm.nih.gov/pubmed/34201335
http://dx.doi.org/10.3390/molecules26123491
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author Pan, Xinhui
Xin, Xiaobing
Mao, Ying
Li, Xin
Zhao, Yanan
Liu, Yidi
Zhang, Ke
Yang, Xiaoda
Wang, Jinhui
author_facet Pan, Xinhui
Xin, Xiaobing
Mao, Ying
Li, Xin
Zhao, Yanan
Liu, Yidi
Zhang, Ke
Yang, Xiaoda
Wang, Jinhui
author_sort Pan, Xinhui
collection PubMed
description In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.
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spelling pubmed-82271292021-06-26 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles Pan, Xinhui Xin, Xiaobing Mao, Ying Li, Xin Zhao, Yanan Liu, Yidi Zhang, Ke Yang, Xiaoda Wang, Jinhui Molecules Article In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive. MDPI 2021-06-08 /pmc/articles/PMC8227129/ /pubmed/34201335 http://dx.doi.org/10.3390/molecules26123491 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pan, Xinhui
Xin, Xiaobing
Mao, Ying
Li, Xin
Zhao, Yanan
Liu, Yidi
Zhang, Ke
Yang, Xiaoda
Wang, Jinhui
3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title_full 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title_fullStr 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title_full_unstemmed 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title_short 3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles
title_sort 3-benzoylisoxazolines by 1,3-dipolar cycloaddition: chloramine-t-catalyzed condensation of α-nitroketones with dipolarophiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227129/
https://www.ncbi.nlm.nih.gov/pubmed/34201335
http://dx.doi.org/10.3390/molecules26123491
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