Cargando…

‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in biological chemistry and biomedicine. CORMs kill bacteria in culture and in animal models, but are reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Southam, Hannah M., Williamson, Michael P., Chapman, Jonathan A., Lyon, Rhiannon L., Trevitt, Clare R., Henderson, Peter J. F., Poole, Robert K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227206/ https://www.ncbi.nlm.nih.gov/pubmed/34198746 http://dx.doi.org/10.3390/antiox10060915

Ejemplares similares

CORM-3 induces DNA damage through Ru(II) binding to DNA
por: Lyon, Rhiannon F., et al.
Publicado: (2022)

The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
por: Murray, Thomas S., et al.
Publicado: (2012)

Carbon monoxide releasing molecule-2 (CORM-2)-liberated CO ameliorates acute pancreatitis
por: Liu, Yishu, et al.
Publicado: (2019)

The effect of carbon monoxide releasing molecule-2 (CORM-2) on healing of ischemic colon anastomosis in rats
por: KAYAPINAR, Ali Kemal, et al.
Publicado: (2021)

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
por: Southam, Hannah M., et al.
Publicado: (2018)

Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
por: Wei, Yunwei, et al.
Publicado: (2010)

The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release
por: Faizan, Muhammad, et al.
Publicado: (2019)

A Structurally-Tunable 3-Hydroxyflavone Motif for Visible Light-Induced Carbon Monoxide-Releasing Molecules (CORMs)**
por: Anderson, Stacey N, et al.
Publicado: (2015)

Carbon monoxide releasing molecule-2 (CORM-2) inhibits growth of multidrug-resistant uropathogenic Escherichia coli in biofilm and following host cell colonization
por: Sahlberg Bang, Charlotte, et al.
Publicado: (2016)

Sensing a CO-Releasing Molecule (CORM) Does Not Equate to Sensing CO: The Case of DPHP and CORM-3
por: Liu, Dongning, et al.
Publicado: (2023)

The Antimicrobial Activity of a Carbon Monoxide Releasing Molecule (EBOR-CORM-1) Is Shaped by Intraspecific Variation within Pseudomonas aeruginosa Populations
por: Flanagan, Lindsey, et al.
Publicado: (2018)

Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death
por: Almeida, Ana S., et al.
Publicado: (2016)

Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage
por: Magierowska, Katarzyna, et al.
Publicado: (2015)

Luminal Administration of a Water-soluble Carbon Monoxide–releasing Molecule (CORM-3) Mitigates Ischemia/Reperfusion Injury in Rats Following Intestinal Transplantation
por: Obara, Takafumi, et al.
Publicado: (2021)

Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor
por: Bauer, Nicola, et al.
Publicado: (2023)

Global gene expression profiling and antibiotic susceptibility after repeated exposure to the carbon monoxide-releasing molecule-2 (CORM-2) in multidrug-resistant ESBL-producing uropathogenic Escherichia coli
por: Sahlberg Bang, Charlotte, et al.
Publicado: (2017)

Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo′' to inhibition by the carbon monoxide-releasing molecule, CORM-3()(): N-acetylcysteine reduces CO-RM uptake and inhibition of respiration
por: Jesse, Helen E., et al.
Publicado: (2013)

CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice
por: Sun, Bingwei, et al.
Publicado: (2008)

The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)
por: Magierowska, Katarzyna, et al.
Publicado: (2016)

Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release
por: Chen, Hui, et al.
Publicado: (2021)

Dentition and Misnomer
por: Monette, George N.
Publicado: (1881)

Protective effects of carbon monoxide releasing molecule-2 on pancreatic function in septic mice
por: Liu, Yishu, et al.
Publicado: (2019)

CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord
por: Zheng, Gang, et al.
Publicado: (2020)

The Bactericidal Activity of Carbon Monoxide–Releasing Molecules against Helicobacter pylori
por: Tavares, Ana F., et al.
Publicado: (2013)

Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells
por: Mu, Xinwei, et al.
Publicado: (2014)

Misnomers in Dermatology: An Update
por: Savitha, Somaiah A, et al.
Publicado: (2013)

The Stethoscope—Laennec's Misnomer
por: Sheridan, James J.
Publicado: (1990)

Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation
por: Decaluwé, Kelly, et al.
Publicado: (2011)

Anti-inflammatory activities of carbon monoxide-releasing molecules (CO-RMs) in the brain
por: Motterlini, Roberto, et al.
Publicado: (2015)

3-Hydroxyflavones and 3-Hydroxy-4-oxoquinolines as Carbon Monoxide-Releasing Molecules
por: Soboleva, Tatiana, et al.
Publicado: (2019)

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation
por: Stamellou, E., et al.
Publicado: (2014)

The Broad-Spectrum Antimicrobial Potential of [Mn(CO)(4)(S(2)CNMe(CH(2)CO(2)H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization
por: Wareham, Lauren K., et al.
Publicado: (2018)

Crohn's Disease—A Misnomer?
por: Harmer, Michael
Publicado: (1988)

"Mental Deficiency": A Misnomer?
por: Crawford, J. M.
Publicado: (1953)

Harm Reduction: A Misnomer
por: King, Nicholas B.
Publicado: (2020)

Watt’s Elevator—A Misnomer
Publicado: (1871)

Is “cellular senescence” a misnomer?
por: Gems, David, et al.
Publicado: (2022)

Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats
por: Zhang, Shulong, et al.
Publicado: (2015)

Inhibition of platelet aggregation by carbon monoxide-releasing molecules (CO-RMs): comparison with NO donors
por: Chlopicki, Stefan, et al.
Publicado: (2012)

Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs)
por: Motterlini, Roberto, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_f7h5s7bttefv20qesm1nobbl8m