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Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress

Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies sh...

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Autores principales: de Sousa, Maria Bernardete Cordeiro, de Meiroz Grilo, Maria Lara Porpino, Galvão-Coelho, Nicole Leite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227430/
https://www.ncbi.nlm.nih.gov/pubmed/34177478
http://dx.doi.org/10.3389/fnbeh.2021.674256
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author de Sousa, Maria Bernardete Cordeiro
de Meiroz Grilo, Maria Lara Porpino
Galvão-Coelho, Nicole Leite
author_facet de Sousa, Maria Bernardete Cordeiro
de Meiroz Grilo, Maria Lara Porpino
Galvão-Coelho, Nicole Leite
author_sort de Sousa, Maria Bernardete Cordeiro
collection PubMed
description Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in relatively stable social groups according to a social hierarchy in which females compete and males cooperate, and form social bonds similar to humans, which makes this species a potential animal model to study disorders related to social stress. In addition, laboratory studies observed the expression of behaviors similar to those in nature and deepened the descriptions of their social and reproductive strategies. They also characterized their responses to the challenge using behavioral, cognitive, physiological, and genetic approaches that were sexually dimorphic and influenced by age and social context. These findings, added to some advantages which indicate good adaptation to captivity and the benefits of the birth of twins, small size, and life cycle in comparison to primates of the Old World, led to their use as animal models for validating psychiatric diseases such as major depression. Juvenile marmosets have recently been used to develop a depression model and to test a psychedelic brew called Ayahuasca from the Amazon rainforest as an alternative treatment for major depression, for which positive results have been found which encourage further studies in adolescents. Therefore, we will review the experimental evidence obtained so far and discuss the extension of the marmoset as an animal model for depression.
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spelling pubmed-82274302021-06-26 Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress de Sousa, Maria Bernardete Cordeiro de Meiroz Grilo, Maria Lara Porpino Galvão-Coelho, Nicole Leite Front Behav Neurosci Behavioral Neuroscience Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in relatively stable social groups according to a social hierarchy in which females compete and males cooperate, and form social bonds similar to humans, which makes this species a potential animal model to study disorders related to social stress. In addition, laboratory studies observed the expression of behaviors similar to those in nature and deepened the descriptions of their social and reproductive strategies. They also characterized their responses to the challenge using behavioral, cognitive, physiological, and genetic approaches that were sexually dimorphic and influenced by age and social context. These findings, added to some advantages which indicate good adaptation to captivity and the benefits of the birth of twins, small size, and life cycle in comparison to primates of the Old World, led to their use as animal models for validating psychiatric diseases such as major depression. Juvenile marmosets have recently been used to develop a depression model and to test a psychedelic brew called Ayahuasca from the Amazon rainforest as an alternative treatment for major depression, for which positive results have been found which encourage further studies in adolescents. Therefore, we will review the experimental evidence obtained so far and discuss the extension of the marmoset as an animal model for depression. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8227430/ /pubmed/34177478 http://dx.doi.org/10.3389/fnbeh.2021.674256 Text en Copyright © 2021 de Sousa, de Meiroz Grilo and Galvão-Coelho. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
de Sousa, Maria Bernardete Cordeiro
de Meiroz Grilo, Maria Lara Porpino
Galvão-Coelho, Nicole Leite
Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title_full Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title_fullStr Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title_full_unstemmed Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title_short Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
title_sort natural and experimental evidence drives marmosets for research on psychiatric disorders related to stress
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227430/
https://www.ncbi.nlm.nih.gov/pubmed/34177478
http://dx.doi.org/10.3389/fnbeh.2021.674256
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