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EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes
Eva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet al...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227468/ https://www.ncbi.nlm.nih.gov/pubmed/34201121 http://dx.doi.org/10.3390/ijms22126181 |
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author | Zhao, Shizhen Wang, Honggang |
author_facet | Zhao, Shizhen Wang, Honggang |
author_sort | Zhao, Shizhen |
collection | PubMed |
description | Eva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet alpha-cell functions, acute liver failure, and hepatitis B virus replication. However, the related mechanisms are not fully clear. Autophagy is a process in which cells transfer pathogens, abnormal proteins and organelles to lysosomes for degradation. It plays an important role in various physiological and pathological processes, including cancer, aging, neurodegeneration, infection, heart disease, development, cell differentiation and nutritional starvation. Recently, there are many studies on the important role of EVA1A in many physiological and pathological processes by regulating autophagy. However, the related molecular mechanisms need further study. Therefore, we summarize the above-mentioned researches about the role of EVA1A in physiological and pathological processes through regulating autophagy in order to provide theoretical basis for future researches. |
format | Online Article Text |
id | pubmed-8227468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82274682021-06-26 EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes Zhao, Shizhen Wang, Honggang Int J Mol Sci Review Eva-1 homolog A (EVA1A) is regarded as TMEM166 (transmembrane protein 166) or FAM176A (family with sequence similarity 176) and a lysosome and endoplasmic reticulum-associated protein involved in regulating autophagy and apoptosis. EVA1A regulates embryonic neurogenesis, cardiac remodeling, islet alpha-cell functions, acute liver failure, and hepatitis B virus replication. However, the related mechanisms are not fully clear. Autophagy is a process in which cells transfer pathogens, abnormal proteins and organelles to lysosomes for degradation. It plays an important role in various physiological and pathological processes, including cancer, aging, neurodegeneration, infection, heart disease, development, cell differentiation and nutritional starvation. Recently, there are many studies on the important role of EVA1A in many physiological and pathological processes by regulating autophagy. However, the related molecular mechanisms need further study. Therefore, we summarize the above-mentioned researches about the role of EVA1A in physiological and pathological processes through regulating autophagy in order to provide theoretical basis for future researches. MDPI 2021-06-08 /pmc/articles/PMC8227468/ /pubmed/34201121 http://dx.doi.org/10.3390/ijms22126181 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhao, Shizhen Wang, Honggang EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title_full | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title_fullStr | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title_full_unstemmed | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title_short | EVA1A Plays an Important Role by Regulating Autophagy in Physiological and Pathological Processes |
title_sort | eva1a plays an important role by regulating autophagy in physiological and pathological processes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227468/ https://www.ncbi.nlm.nih.gov/pubmed/34201121 http://dx.doi.org/10.3390/ijms22126181 |
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