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Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227491/ https://www.ncbi.nlm.nih.gov/pubmed/34070716 http://dx.doi.org/10.3390/microorganisms9061179 |
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author | Soliman, Shimaa Hassan AbdelAziz Orlacchio, Arturo Verginelli, Fabio |
author_facet | Soliman, Shimaa Hassan AbdelAziz Orlacchio, Arturo Verginelli, Fabio |
author_sort | Soliman, Shimaa Hassan AbdelAziz |
collection | PubMed |
description | Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection. |
format | Online Article Text |
id | pubmed-8227491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82274912021-06-26 Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis Soliman, Shimaa Hassan AbdelAziz Orlacchio, Arturo Verginelli, Fabio Microorganisms Review Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection. MDPI 2021-05-30 /pmc/articles/PMC8227491/ /pubmed/34070716 http://dx.doi.org/10.3390/microorganisms9061179 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Soliman, Shimaa Hassan AbdelAziz Orlacchio, Arturo Verginelli, Fabio Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title | Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title_full | Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title_fullStr | Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title_full_unstemmed | Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title_short | Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis |
title_sort | viral manipulation of the host epigenome as a driver of virus-induced oncogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227491/ https://www.ncbi.nlm.nih.gov/pubmed/34070716 http://dx.doi.org/10.3390/microorganisms9061179 |
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