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Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses i...

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Autores principales: Soliman, Shimaa Hassan AbdelAziz, Orlacchio, Arturo, Verginelli, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227491/
https://www.ncbi.nlm.nih.gov/pubmed/34070716
http://dx.doi.org/10.3390/microorganisms9061179
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author Soliman, Shimaa Hassan AbdelAziz
Orlacchio, Arturo
Verginelli, Fabio
author_facet Soliman, Shimaa Hassan AbdelAziz
Orlacchio, Arturo
Verginelli, Fabio
author_sort Soliman, Shimaa Hassan AbdelAziz
collection PubMed
description Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection.
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spelling pubmed-82274912021-06-26 Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis Soliman, Shimaa Hassan AbdelAziz Orlacchio, Arturo Verginelli, Fabio Microorganisms Review Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection. MDPI 2021-05-30 /pmc/articles/PMC8227491/ /pubmed/34070716 http://dx.doi.org/10.3390/microorganisms9061179 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Soliman, Shimaa Hassan AbdelAziz
Orlacchio, Arturo
Verginelli, Fabio
Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title_full Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title_fullStr Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title_full_unstemmed Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title_short Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
title_sort viral manipulation of the host epigenome as a driver of virus-induced oncogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227491/
https://www.ncbi.nlm.nih.gov/pubmed/34070716
http://dx.doi.org/10.3390/microorganisms9061179
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