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Ubiquitin-Conjugating Enzymes in Cancer

The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein...

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Autores principales: Bui, Quyen Thu, Hong, Jeong Hee, Kwak, Minseok, Lee, Ji Yeon, Lee, Peter Chang-Whan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227520/
https://www.ncbi.nlm.nih.gov/pubmed/34199813
http://dx.doi.org/10.3390/cells10061383
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author Bui, Quyen Thu
Hong, Jeong Hee
Kwak, Minseok
Lee, Ji Yeon
Lee, Peter Chang-Whan
author_facet Bui, Quyen Thu
Hong, Jeong Hee
Kwak, Minseok
Lee, Ji Yeon
Lee, Peter Chang-Whan
author_sort Bui, Quyen Thu
collection PubMed
description The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.
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spelling pubmed-82275202021-06-26 Ubiquitin-Conjugating Enzymes in Cancer Bui, Quyen Thu Hong, Jeong Hee Kwak, Minseok Lee, Ji Yeon Lee, Peter Chang-Whan Cells Review The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies. MDPI 2021-06-04 /pmc/articles/PMC8227520/ /pubmed/34199813 http://dx.doi.org/10.3390/cells10061383 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bui, Quyen Thu
Hong, Jeong Hee
Kwak, Minseok
Lee, Ji Yeon
Lee, Peter Chang-Whan
Ubiquitin-Conjugating Enzymes in Cancer
title Ubiquitin-Conjugating Enzymes in Cancer
title_full Ubiquitin-Conjugating Enzymes in Cancer
title_fullStr Ubiquitin-Conjugating Enzymes in Cancer
title_full_unstemmed Ubiquitin-Conjugating Enzymes in Cancer
title_short Ubiquitin-Conjugating Enzymes in Cancer
title_sort ubiquitin-conjugating enzymes in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227520/
https://www.ncbi.nlm.nih.gov/pubmed/34199813
http://dx.doi.org/10.3390/cells10061383
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