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Ubiquitin-Conjugating Enzymes in Cancer
The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227520/ https://www.ncbi.nlm.nih.gov/pubmed/34199813 http://dx.doi.org/10.3390/cells10061383 |
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author | Bui, Quyen Thu Hong, Jeong Hee Kwak, Minseok Lee, Ji Yeon Lee, Peter Chang-Whan |
author_facet | Bui, Quyen Thu Hong, Jeong Hee Kwak, Minseok Lee, Ji Yeon Lee, Peter Chang-Whan |
author_sort | Bui, Quyen Thu |
collection | PubMed |
description | The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies. |
format | Online Article Text |
id | pubmed-8227520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82275202021-06-26 Ubiquitin-Conjugating Enzymes in Cancer Bui, Quyen Thu Hong, Jeong Hee Kwak, Minseok Lee, Ji Yeon Lee, Peter Chang-Whan Cells Review The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies. MDPI 2021-06-04 /pmc/articles/PMC8227520/ /pubmed/34199813 http://dx.doi.org/10.3390/cells10061383 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bui, Quyen Thu Hong, Jeong Hee Kwak, Minseok Lee, Ji Yeon Lee, Peter Chang-Whan Ubiquitin-Conjugating Enzymes in Cancer |
title | Ubiquitin-Conjugating Enzymes in Cancer |
title_full | Ubiquitin-Conjugating Enzymes in Cancer |
title_fullStr | Ubiquitin-Conjugating Enzymes in Cancer |
title_full_unstemmed | Ubiquitin-Conjugating Enzymes in Cancer |
title_short | Ubiquitin-Conjugating Enzymes in Cancer |
title_sort | ubiquitin-conjugating enzymes in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227520/ https://www.ncbi.nlm.nih.gov/pubmed/34199813 http://dx.doi.org/10.3390/cells10061383 |
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