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Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association

Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to i...

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Autores principales: Sebastiani, Marco, Luppi, Fabrizio, Sambataro, Gianluca, Castillo Villegas, Diego, Cerri, Stefania, Tomietto, Paola, Cassone, Giulia, Bocchino, Marialuisa, Atienza-Mateo, Belen, Cameli, Paolo, Moya Alvarado, Patricia, Faverio, Paola, Bargagli, Elena, Vancheri, Carlo, Gonzalez-Gay, Miguel A., Clini, Enrico, Salvarani, Carlo, Manfredi, Andreina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227546/
https://www.ncbi.nlm.nih.gov/pubmed/34207641
http://dx.doi.org/10.3390/jcm10122548
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author Sebastiani, Marco
Luppi, Fabrizio
Sambataro, Gianluca
Castillo Villegas, Diego
Cerri, Stefania
Tomietto, Paola
Cassone, Giulia
Bocchino, Marialuisa
Atienza-Mateo, Belen
Cameli, Paolo
Moya Alvarado, Patricia
Faverio, Paola
Bargagli, Elena
Vancheri, Carlo
Gonzalez-Gay, Miguel A.
Clini, Enrico
Salvarani, Carlo
Manfredi, Andreina
author_facet Sebastiani, Marco
Luppi, Fabrizio
Sambataro, Gianluca
Castillo Villegas, Diego
Cerri, Stefania
Tomietto, Paola
Cassone, Giulia
Bocchino, Marialuisa
Atienza-Mateo, Belen
Cameli, Paolo
Moya Alvarado, Patricia
Faverio, Paola
Bargagli, Elena
Vancheri, Carlo
Gonzalez-Gay, Miguel A.
Clini, Enrico
Salvarani, Carlo
Manfredi, Andreina
author_sort Sebastiani, Marco
collection PubMed
description Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 ± 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease.
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spelling pubmed-82275462021-06-26 Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association Sebastiani, Marco Luppi, Fabrizio Sambataro, Gianluca Castillo Villegas, Diego Cerri, Stefania Tomietto, Paola Cassone, Giulia Bocchino, Marialuisa Atienza-Mateo, Belen Cameli, Paolo Moya Alvarado, Patricia Faverio, Paola Bargagli, Elena Vancheri, Carlo Gonzalez-Gay, Miguel A. Clini, Enrico Salvarani, Carlo Manfredi, Andreina J Clin Med Article Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 ± 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease. MDPI 2021-06-09 /pmc/articles/PMC8227546/ /pubmed/34207641 http://dx.doi.org/10.3390/jcm10122548 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sebastiani, Marco
Luppi, Fabrizio
Sambataro, Gianluca
Castillo Villegas, Diego
Cerri, Stefania
Tomietto, Paola
Cassone, Giulia
Bocchino, Marialuisa
Atienza-Mateo, Belen
Cameli, Paolo
Moya Alvarado, Patricia
Faverio, Paola
Bargagli, Elena
Vancheri, Carlo
Gonzalez-Gay, Miguel A.
Clini, Enrico
Salvarani, Carlo
Manfredi, Andreina
Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title_full Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title_fullStr Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title_full_unstemmed Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title_short Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
title_sort interstitial lung disease and anti-myeloperoxidase antibodies: not a simple association
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227546/
https://www.ncbi.nlm.nih.gov/pubmed/34207641
http://dx.doi.org/10.3390/jcm10122548
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