Cargando…
Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association
Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to i...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227546/ https://www.ncbi.nlm.nih.gov/pubmed/34207641 http://dx.doi.org/10.3390/jcm10122548 |
_version_ | 1783712548081631232 |
---|---|
author | Sebastiani, Marco Luppi, Fabrizio Sambataro, Gianluca Castillo Villegas, Diego Cerri, Stefania Tomietto, Paola Cassone, Giulia Bocchino, Marialuisa Atienza-Mateo, Belen Cameli, Paolo Moya Alvarado, Patricia Faverio, Paola Bargagli, Elena Vancheri, Carlo Gonzalez-Gay, Miguel A. Clini, Enrico Salvarani, Carlo Manfredi, Andreina |
author_facet | Sebastiani, Marco Luppi, Fabrizio Sambataro, Gianluca Castillo Villegas, Diego Cerri, Stefania Tomietto, Paola Cassone, Giulia Bocchino, Marialuisa Atienza-Mateo, Belen Cameli, Paolo Moya Alvarado, Patricia Faverio, Paola Bargagli, Elena Vancheri, Carlo Gonzalez-Gay, Miguel A. Clini, Enrico Salvarani, Carlo Manfredi, Andreina |
author_sort | Sebastiani, Marco |
collection | PubMed |
description | Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 ± 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease. |
format | Online Article Text |
id | pubmed-8227546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82275462021-06-26 Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association Sebastiani, Marco Luppi, Fabrizio Sambataro, Gianluca Castillo Villegas, Diego Cerri, Stefania Tomietto, Paola Cassone, Giulia Bocchino, Marialuisa Atienza-Mateo, Belen Cameli, Paolo Moya Alvarado, Patricia Faverio, Paola Bargagli, Elena Vancheri, Carlo Gonzalez-Gay, Miguel A. Clini, Enrico Salvarani, Carlo Manfredi, Andreina J Clin Med Article Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 ± 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease. MDPI 2021-06-09 /pmc/articles/PMC8227546/ /pubmed/34207641 http://dx.doi.org/10.3390/jcm10122548 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sebastiani, Marco Luppi, Fabrizio Sambataro, Gianluca Castillo Villegas, Diego Cerri, Stefania Tomietto, Paola Cassone, Giulia Bocchino, Marialuisa Atienza-Mateo, Belen Cameli, Paolo Moya Alvarado, Patricia Faverio, Paola Bargagli, Elena Vancheri, Carlo Gonzalez-Gay, Miguel A. Clini, Enrico Salvarani, Carlo Manfredi, Andreina Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title | Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title_full | Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title_fullStr | Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title_full_unstemmed | Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title_short | Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association |
title_sort | interstitial lung disease and anti-myeloperoxidase antibodies: not a simple association |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227546/ https://www.ncbi.nlm.nih.gov/pubmed/34207641 http://dx.doi.org/10.3390/jcm10122548 |
work_keys_str_mv | AT sebastianimarco interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT luppifabrizio interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT sambatarogianluca interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT castillovillegasdiego interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT cerristefania interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT tomiettopaola interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT cassonegiulia interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT bocchinomarialuisa interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT atienzamateobelen interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT camelipaolo interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT moyaalvaradopatricia interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT faveriopaola interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT bargaglielena interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT vanchericarlo interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT gonzalezgaymiguela interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT clinienrico interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT salvaranicarlo interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation AT manfrediandreina interstitiallungdiseaseandantimyeloperoxidaseantibodiesnotasimpleassociation |