Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip

Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. Case report: In this paper, we report the case of an 86-year-old patient with a well-diffe...

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Autores principales: Pentangelo, Giovanni, Nisticò, Steven Paul, Provenzano, Eugenio, Cisale, Giusy Ylenia, Bennardo, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227566/
https://www.ncbi.nlm.nih.gov/pubmed/34199380
http://dx.doi.org/10.3390/medicina57060563
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author Pentangelo, Giovanni
Nisticò, Steven Paul
Provenzano, Eugenio
Cisale, Giusy Ylenia
Bennardo, Luigi
author_facet Pentangelo, Giovanni
Nisticò, Steven Paul
Provenzano, Eugenio
Cisale, Giusy Ylenia
Bennardo, Luigi
author_sort Pentangelo, Giovanni
collection PubMed
description Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. Case report: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred. Conclusions: Topical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.
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spelling pubmed-82275662021-06-26 Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip Pentangelo, Giovanni Nisticò, Steven Paul Provenzano, Eugenio Cisale, Giusy Ylenia Bennardo, Luigi Medicina (Kaunas) Case Report Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. Case report: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred. Conclusions: Topical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses. MDPI 2021-06-02 /pmc/articles/PMC8227566/ /pubmed/34199380 http://dx.doi.org/10.3390/medicina57060563 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pentangelo, Giovanni
Nisticò, Steven Paul
Provenzano, Eugenio
Cisale, Giusy Ylenia
Bennardo, Luigi
Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title_full Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title_fullStr Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title_full_unstemmed Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title_short Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip
title_sort topical 5% imiquimod sequential to surgery for hpv-related squamous cell carcinoma of the lip
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227566/
https://www.ncbi.nlm.nih.gov/pubmed/34199380
http://dx.doi.org/10.3390/medicina57060563
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